PURPOSE: To determine the relative importance of lens geometry and mechanical properties for the mechanics of accommodation and the role of these elements in the causes and potential correction of presbyopia. SETTING: Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey, USA. DESIGN: Experimental study. METHODS: Finite element methods and ray-tracing algorithms were used to model the deformation and optical power of the human crystalline lens during accommodation. The mechanical model treats the lens as an axisymmetric object, and the optical model incorporates a gradient refractive index. Using these models, the accommodation of a broad range of lenses with different geometries and mechanical properties were investigated. RESULTS: The most significant result was that reshaping the 45-year-old lens to the geometry of the 29-year-old lens, while retaining the mechanical properties, restored the former's accommodation amplitude to 72% to 94% of that of the 29-year-old lens, depending on ciliary body displacement. That is, reshaping can add 1.8 to 3.7 diopters of accommodation. A sensitivity analysis showed that this result was robust over a wide range of mechanical and geometrical properties. CONCLUSION: The study results suggest that a significant amount of the loss of accommodation is due to changes in lens geometry.
PURPOSE: To determine the relative importance of lens geometry and mechanical properties for the mechanics of accommodation and the role of these elements in the causes and potential correction of presbyopia. SETTING: Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey, USA. DESIGN: Experimental study. METHODS: Finite element methods and ray-tracing algorithms were used to model the deformation and optical power of the human crystalline lens during accommodation. The mechanical model treats the lens as an axisymmetric object, and the optical model incorporates a gradient refractive index. Using these models, the accommodation of a broad range of lenses with different geometries and mechanical properties were investigated. RESULTS: The most significant result was that reshaping the 45-year-old lens to the geometry of the 29-year-old lens, while retaining the mechanical properties, restored the former's accommodation amplitude to 72% to 94% of that of the 29-year-old lens, depending on ciliary body displacement. That is, reshaping can add 1.8 to 3.7 diopters of accommodation. A sensitivity analysis showed that this result was robust over a wide range of mechanical and geometrical properties. CONCLUSION: The study results suggest that a significant amount of the loss of accommodation is due to changes in lens geometry.
Authors: Georgios Zoulinakis; Jose Juan Esteve-Taboada; Teresa Ferrer-Blasco; David Madrid-Costa; Robert Montés-Micó Journal: Int J Ophthalmol Date: 2017-01-18 Impact factor: 1.779
Authors: Andrzej Grzybowski; Ronald A Schachar; Magdalena Gaca-Wysocka; Ira H Schachar; Farhad Kamangar; Barbara K Pierscionek Journal: Graefes Arch Clin Exp Ophthalmol Date: 2017-11-16 Impact factor: 3.117