AIM: The orexigenic hormone, ghrelin, is linked to learning and memory in animal studies. No previous study has investigated whether cognition is related to ghrelin in the non-demented elderly. METHODS: Thirty-five older adults underwent neuropsychological testing and fasting blood draw with subsequent serum ghrelin quantification. RESULTS: Ghrelin was negatively correlated with several cognitive domains, including verbal memory, working memory, and naming. CONCLUSION: Areas of cognition associated with ghrelin level were similar to the pattern of deficits observed in early Alzheimer's disease. Findings suggest a potential moderational role of ghrelin in pathological cognitive decline. Further work investigating mechanisms is needed.
AIM: The orexigenic hormone, ghrelin, is linked to learning and memory in animal studies. No previous study has investigated whether cognition is related to ghrelin in the non-demented elderly. METHODS: Thirty-five older adults underwent neuropsychological testing and fasting blood draw with subsequent serum ghrelin quantification. RESULTS:Ghrelin was negatively correlated with several cognitive domains, including verbal memory, working memory, and naming. CONCLUSION: Areas of cognition associated with ghrelin level were similar to the pattern of deficits observed in early Alzheimer's disease. Findings suggest a potential moderational role of ghrelin in pathological cognitive decline. Further work investigating mechanisms is needed.
Authors: A Theodoropoulou; I C Metallinos; A Psyrogiannis; G A Vagenakis; V Kyriazopoulou Journal: J Nutr Health Aging Date: 2012-05 Impact factor: 4.075
Authors: Luanna Dixson; Henrik Walter; Michael Schneider; Susanne Erk; Axel Schäfer; Leila Haddad; Oliver Grimm; Manuel Mattheisen; Markus M Nöthen; Sven Cichon; Stephanie H Witt; Marcella Rietschel; Sebastian Mohnke; Nina Seiferth; Andreas Heinz; Heike Tost; Andreas Meyer-Lindenberg Journal: Proc Natl Acad Sci U S A Date: 2014-06-16 Impact factor: 11.205
Authors: Rachel Galioto; Wendy C King; Dale S Bond; Mary Beth Spitznagel; Gladys Strain; Michael Devlin; Ronald Cohen; Ross D Crosby; James E Mitchell; John Gunstad Journal: Int J Neurosci Date: 2014-03-24 Impact factor: 2.292