Literature DB >> 210200

Enhanced collagenase activity in diabetic rat gingiva: in vitro and in vivo evidence.

L M Golub, M Schneir, N S Ramamurthy.   

Abstract

Gingiva from alloxan and streptozotocin-diabetic rats exhibited markedly enhanced collagenolytic activity in tissue culture. This effect was eliminated by puromycin or by repeated freeze-thawing of the tissue prior to incubation. Soluble extracts of the diabetic gingiva in situ were found to contain breakdown products of collagen similar in size to the reaction products generated by tissue collagenase. These fragments were not detected in the control tissue. This study indicates that experimental diabetes stimulates the synthesis of gingival collagenase in culture and that a similar effect occurs in vivo.

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Year:  1978        PMID： 210200     DOI： 10.1177/00220345780570032101

Source DB:  PubMed          Journal:  J Dent Res        ISSN： 0022-0345            Impact factor:   6.116


  8 in total

1.  Suppressed collagenolytic activity in polymorphonuclear leucocytes from diabetic humans.

Authors:  G A Nicoll; G M Gollapudi; N S Ramamurthy; L M Golub
Journal:  Experientia       Date:  1981-03-15

2.  Levels of salivary lysozyme, lactoperoxidase, and lactoferrin in diabetic hamsters.

Authors:  K Muratsu; T Morioka
Journal:  Infect Immun       Date:  1985-05       Impact factor: 3.441

3.  Periodontitis predicts HbA1c levels and glucose variability in type 1 diabetic patients: the PARODIA Florence Project study.

Authors:  Francesco Cairo; Ilaria Dicembrini; Lapo Serni; Michele Nieri; Guido Bettarini; Mariasmeralda Caliri; Laura Pala; Edoardo Mannucci; Luigi Barbato
Journal:  Clin Oral Investig       Date:  2022-01-15       Impact factor: 3.573

4.  Comparative analysis of coherent light action (laser) versus non-coherent light (light-emitting diode) for tissue repair in diabetic rats.

Authors:  Mauro Antônio Dall Agnol; Renata Amadei Nicolau; Carlos José de Lima; Egberto Munin
Journal:  Lasers Med Sci       Date:  2009-02-24       Impact factor: 3.161

5.  In vivo crevicular leukocyte response to a chemotactic challenge: inhibition by experimental diabetes.

Authors:  L M Golub; G A Nicoll; V J Iacono; N S Ramamurthy
Journal:  Infect Immun       Date:  1982-09       Impact factor: 3.441

6.  Influence of streptozotocin- and alloxan-induced diabetes in the rat on collagenase and certain lysosomal enzymes in relation to the degradation of connective tissue proteins.

Authors:  S Mohanam; S M Bose
Journal:  Diabetologia       Date:  1983-07       Impact factor: 10.122

7.  Alloxan-induced diabetes triggers the development of periodontal disease in rats.

Authors:  Marcela Claudino; Danielle Santi Ceolin; Sandra Alberti; Tania Mary Cestari; César Tadeu Spadella; Izabel Regina Fischer Rubira-Bullen; Gustavo Pompermaier Garlet; Gerson Francisco de Assis
Journal:  PLoS One       Date:  2007-12-19       Impact factor: 3.240

8.  Green tea extract as a local drug therapy on periodontitis patients with diabetes mellitus: A randomized case-control study.

Authors:  Jayaprakash S Gadagi; Vijay K Chava; Venkata Ramesh Reddy
Journal:  J Indian Soc Periodontol       Date:  2013-03
  8 in total

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