Literature DB >> 210137

Temperature-sensitive mutants of simian virus 40. I. Isolation aand preliminary characterization of B/C gene mutants.

C A Noonan, J S Butel.   

Abstract

Sixteen temperature-sensitive mutants of simian virus 40 were isolated after treatment of wild-type virus with UV light, nitrous acid, or nitrosoguanidine. All of the mutants were assigned to the B complementation group on the basis of quantitative complementation analyses. Characterization of several representative mutants revealed that under restrictive conditions such mutants produced immunologically identifiable tumor and viral capsid antigens, induced the synthesis of cellular DNA, and replicated infectious viral DNA. In addition, mutant particles produced at 33 degrees were more heat-labile than wild-type virus. This collection of mutants will be useful in an analysis of SV40 particle morphogenesis.

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Year:  1978        PMID： 210137     DOI： 10.1159/000148982

Source DB:  PubMed          Journal:  Intervirology        ISSN： 0300-5526            Impact factor:   1.763


  7 in total

1.  The cellular secretory pathway is not utilized for biosynthesis, modification, or intracellular transport of the simian virus 40 large tumor antigen.

Authors:  D L Jarvis; W K Chan; M K Estes; J S Butel
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

2.  A structural rationale for SV40 Vp1 temperature-sensitive mutants and their complementation.

Authors:  Harumi Kasamatsu; Jennifer Woo; Akiko Nakamura; Peter Müller; M Judith Tevethia; Robert C Liddington
Journal:  Protein Sci       Date:  2006-08-01       Impact factor: 6.725

3.  Natural isolates of simian virus 40 from immunocompromised monkeys display extensive genetic heterogeneity: new implications for polyomavirus disease.

Authors:  J A Lednicky; A S Arrington; A R Stewart; X M Dai; C Wong; S Jafar; M Murphey-Corb; J S Butel
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

4.  Absence of a structural basis for intracellular recognition and differential localization of nuclear and plasma membrane-associated forms of simian virus 40 large tumor antigen.

Authors:  D L Jarvis; C N Cole; J S Butel
Journal:  Mol Cell Biol       Date:  1986-03       Impact factor: 4.272

5.  Antigenic structure of simian virus 40 large tumor antigen and association with cellular protein p53 on the surfaces of simian virus 40-infected and -transformed cells.

Authors:  M Santos; J S Butel
Journal:  J Virol       Date:  1984-08       Impact factor: 5.103

6.  Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies.

Authors:  R C Kennedy; G R Dreesman; J S Butel; R E Lanford
Journal:  J Exp Med       Date:  1985-06-01       Impact factor: 14.307

7.  Modification of simian virus 40 large tumor antigen by glycosylation.

Authors:  D L Jarvis; J S Butel
Journal:  Virology       Date:  1985-03       Impact factor: 3.616
  7 in total

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