| Literature DB >> 2101094 |
J P Leite1, E M Nakamura, T Lemos, J Masur, E A Cavalheiro.
Abstract
Male Wistar rats were subjected to pilocarpine-induced status epilepticus and allowed to recover. After reaching the chronic state with spontaneous seizures they were tested in an 8-arm radial maze. During learning trials, epileptic rats made significantly more errors than controls. Even in the last trials epileptic rats did not improve their performance, indicating severe learning disability. These results suggest that spontaneous seizures after pilocarpine-induced status epilepticus are a useful model for studying the learning and memory impairment detected in some cases of symptomatic epilepsy.Entities:
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Year: 1990 PMID： 2101094
Source DB: PubMed Journal: Braz J Med Biol Res ISSN： 0100-879X Impact factor: 2.590