Literature DB >> 2100411

An unidentified macromolecular inhibitory constituent of calcium oxalate crystal growth in human urine.

S Sørensen1, K Hansen, S Bak, S J Justesen.   

Abstract

We have detected and isolated a macromolecular constituent in normal human urine possessing calcium crystal growth inhibitory activity. The purification procedure consisted of two anion exchange chromatographies and one affinity chromatography. The crystal growth inhibitor was found to be heterogeneous in net charge as well as in size. It has not been identified. It is not an uronic acid-containing glycosaminoglycan, hitherto presumed to be responsible for the inhibitory activity. Whether an urinary fragment of inter-alpha-trypsin inhibitor is responsible has yet to be resolved.

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Year:  1990        PMID： 2100411     DOI： 10.1007/bf00297368

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  26 in total

1.  Inhibitory effects of urinary macromolecules on the crystallization of calcium oxalate.

Authors:  W B Gill; J W Karesh; L Garsin; M J Roma
Journal:  Invest Urol       Date:  1977-09

2.  New method for quantitative determination of uronic acids.

Authors:  N Blumenkrantz; G Asboe-Hansen
Journal:  Anal Biochem       Date:  1973-08       Impact factor: 3.365

3.  The effect of saline bladder washings on calcium oxalate crystal growth and aggregation.

Authors:  K A Edyvane; R L Ryall; V R Marshall
Journal:  J Urol       Date:  1985-07       Impact factor: 7.450

4.  Purification and characterization of a calcium oxalate monohydrate crystal growth inhibitor from human kidney tissue culture medium.

Authors:  Y Nakagawa; H C Margolis; S Yokoyama; F J Kézdy; E T Kaiser; F L Coe
Journal:  J Biol Chem       Date:  1981-04-25       Impact factor: 5.157

5.  A specific, sensitive method for the determination of hyaluronate.

Authors:  G W Jourdian; M Wolfman; R Sarber; J Distler
Journal:  Anal Biochem       Date:  1979-07-15       Impact factor: 3.365

6.  Acidic peptide and polyribonucleotide crystal growth inhibitors in human urine.

Authors:  H Ito; F L Coe
Journal:  Am J Physiol       Date:  1977-11

7.  Aggregation of calcium oxalate crystals: effect of urine and various inhibitors.

Authors:  R Felix; A Monod; L Broge; N M Hansen; H Fleisch
Journal:  Urol Res       Date:  1977

8.  Ca2+-binding protein from human kidney. Purification and properties.

Authors:  M Staun; O Norén; H Sjöström
Journal:  Biochem J       Date:  1984-01-01       Impact factor: 3.857

9.  Bladder secretion of inhibitors of calcium oxalate crystal growth.

Authors:  X Martin; T J Opgennorth; P G Werness; R T Rundquist; J C Romero; L H Smith
Journal:  Kidney Int       Date:  1985-10       Impact factor: 10.612

10.  Dermatan sulphate in urine reflects the extent of skin affection in psoriasis.

Authors:  J H Poulsen; M K Cramers
Journal:  Clin Chim Acta       Date:  1982-12-09       Impact factor: 3.786
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  9 in total

Review 1.  Urinary inhibitors of calcium oxalate crystallization and their potential role in stone formation.

Authors:  R L Ryall
Journal:  World J Urol       Date:  1997       Impact factor: 4.226

Review 2.  Glycosaminoglycans, proteins, and stone formation: adult themes and child's play.

Authors:  R L Ryall
Journal:  Pediatr Nephrol       Date:  1996-10       Impact factor: 3.714

3.  Isolation and partial characterization of crystal matrix protein as a potent inhibitor of calcium oxalate crystal aggregation: evidence of activation peptide of human prothrombin.

Authors:  K Suzuki; M Moriyama; C Nakajima; K Kawamura; K Miyazawa; R Tsugawa; N Kikuchi; K Nagata
Journal:  Urol Res       Date:  1994

4.  Reduced inhibitory activity of uronic-acid-rich protein in urine of stone formers.

Authors:  F Atmani; B Lacour; P Jungers; T Drüeke; M Daudon
Journal:  Urol Res       Date:  1994

5.  Identification of a macromolecular crystal growth inhibitor in human urine as osteopontin.

Authors:  S Sørensen; S J Justesen; A H Johnsen
Journal:  Urol Res       Date:  1995

6.  Isolation and purification of a new glycoprotein from human urine inhibiting calcium oxalate crystallization.

Authors:  F Atmani; B Lacour; T Drüeke; M Daudon
Journal:  Urol Res       Date:  1993-01

7.  Calcium oxalate crystal matrix extract: the most potent macromolecular inhibitor of crystal growth and aggregation yet tested in undiluted human urine in vitro.

Authors:  I R Doyle; V R Marshall; C J Dawson; R L Ryall
Journal:  Urol Res       Date:  1995

8.  Characterization of uronic-acid-rich inhibitor of calcium oxalate crystallization isolated from rat urine.

Authors:  F Atmani; S R Khan
Journal:  Urol Res       Date:  1995

Review 9.  Induced urinary crystal formation as an analytical strategy for the prediction and monitoring of urolithiasis and other metabolism-related disorders.

Authors:  Norbert Laube; Wolfgang Berg; Falk Bernsmann; Sascha Gravius; Florian Klein; Stefan Latz; Dirk von Mallek; Tadeusz Porowski; Thomas Randau; Anna Wasilewska; Christian Fisang
Journal:  EPMA J       Date:  2014-08-16       Impact factor: 6.543
  9 in total

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