Convenient synthesis of 1-phenyl-1,2-propanediamines. Preliminary pharmacological results.

A novel synthesis of (1R,2S)- and (1S,2S)-1-phenyl-1,2-propanediamines by highly regioselective and stereo-specific opening of chiral aziridines is reported. This method permits the synthesis of optically pure diastereomers. A hypothermic effect is observed after intracerebroventricular injection in rats.