Literature DB >> 2099735

An assessment of COMPOSER: a rule-based approach to modelling protein structure.

C M Topham1, P Thomas, J P Overington, M S Johnson, F Eisenmenger, T L Blundell.   

Abstract

We describe COMPOSER, a computer program for modelling proteins which uses three-dimensional structures defined by X-ray analysis together with rules defined by their analysis and comparison. We discuss the modelling of phospholipases and serine proteinases of known structure to assess the errors associated with such models.

Mesh：

Substances：

Year:  1990        PMID： 2099735

Source DB:  PubMed          Journal:  Biochem Soc Symp        ISSN： 0067-8694


  10 in total

1.  Refinement of modelled structures by knowledge-based energy profiles and secondary structure prediction: application to the human procarboxypeptidase A2.

Authors:  P Aloy; J M Mas; M A Martí-Renom; E Querol; F X Avilés; B Oliva
Journal:  J Comput Aided Mol Des       Date:  2000-01       Impact factor: 3.686

2.  Protein structure homology modeling using SWISS-MODEL workspace.

Authors:  Lorenza Bordoli; Florian Kiefer; Konstantin Arnold; Pascal Benkert; James Battey; Torsten Schwede
Journal:  Nat Protoc       Date:  2009       Impact factor: 13.491

3.  Patterns and conformations of commonly occurring supersecondary structures (basic motifs) in protein data bank.

Authors:  Z Sun; B Jiang
Journal:  J Protein Chem       Date:  1996-10

4.  Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins.

Authors:  Michael R Yeaman; Nannette Y Yount; Alan J Waring; Kimberly D Gank; Deborah Kupferwasser; Robert Wiese; Arnold S Bayer; William H Welch
Journal:  Biochim Biophys Acta       Date:  2006-11-30

5.  Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP).

Authors:  L E Donate; E Gherardi; N Srinivasan; R Sowdhamini; S Aparicio; T L Blundell
Journal:  Protein Sci       Date:  1994-12       Impact factor: 6.725

6.  Platelet microbicidal protein 1: structural themes of a multifunctional antimicrobial peptide.

Authors:  Nannette Y Yount; Kimberly D Gank; Yan Qiong Xiong; Arnold S Bayer; Thomas Pender; William H Welch; Michael R Yeaman
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

7.  Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papain.

Authors:  M P Thomas; C M Topham; D Kowlessur; G W Mellor; E W Thomas; D Whitford; K Brocklehurst
Journal:  Biochem J       Date:  1994-06-15       Impact factor: 3.857

8.  Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis.

Authors:  C M Topham; E Salih; C Frazao; D Kowlessur; J P Overington; M Thomas; S M Brocklehurst; M Patel; E W Thomas; K Brocklehurst
Journal:  Biochem J       Date:  1991-11-15       Impact factor: 3.857

9.  Comparative modelling by restraint-based conformational sampling.

Authors:  Nicholas Furnham; Paul Iw de Bakker; Swanand Gore; David F Burke; Tom L Blundell
Journal:  BMC Struct Biol       Date:  2008-01-31

10.  Exploring the Interaction Mechanism Between Cyclopeptide DC3 and Androgen Receptor Using Molecular Dynamics Simulations and Free Energy Calculations.

Authors:  Huimin Zhang; Tianqing Song; Yizhao Yang; Chenggong Fu; Jiazhong Li
Journal:  Front Chem       Date:  2018-04-19       Impact factor: 5.221
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.