Literature DB >> 20980818

Repeat-element driven activation of proto-oncogenes in human malignancies.

Björn Lamprecht1, Constanze Bonifer, Stephan Mathas.   

Abstract

Recent data demonstrated that the aberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the pathogenesis and therapy of human cancer.

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Year:  2010        PMID： 20980818      PMCID： PMC3055180          DOI： 10.4161/cc.9.21.13682

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  56 in total

1.  Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells.

Authors:  F Emmerich; M Meiser; M Hummel; G Demel; H D Foss; F Jundt; S Mathas; D Krappmann; C Scheidereit; H Stein; B Dörken
Journal:  Blood       Date:  1999-11-01       Impact factor: 22.113

2.  Immunohistochemical detection of cells positive for colony-stimulating factor 1 in lymph nodes from reactive lymphadenitis, and Hodgkin's disease.

Authors:  A Moreau; V Praloran; L Berrada; L Coupey; F Gaillard
Journal:  Leukemia       Date:  1992-02       Impact factor: 11.528

Review 3.  Targeting cancer with small molecule kinase inhibitors.

Authors:  Jianming Zhang; Priscilla L Yang; Nathanael S Gray
Journal:  Nat Rev Cancer       Date:  2009-01       Impact factor: 60.716

Review 4.  Effects of retroviruses on host genome function.

Authors:  Patric Jern; John M Coffin
Journal:  Annu Rev Genet       Date:  2008       Impact factor: 16.830

Review 5.  Linking DNA methylation and histone modification: patterns and paradigms.

Authors:  Howard Cedar; Yehudit Bergman
Journal:  Nat Rev Genet       Date:  2009-05       Impact factor: 53.242

Review 6.  The fundamental role of epigenetic events in cancer.

Authors:  Peter A Jones; Stephen B Baylin
Journal:  Nat Rev Genet       Date:  2002-06       Impact factor: 53.242

7.  Overexpression of c-met as a prognostic indicator for transitional cell carcinoma of the urinary bladder: a comparison with p53 nuclear accumulation.

Authors:  Hong-Lin Cheng; Barry Trink; Tzong-Shin Tzai; Hsiao-Sheng Liu; Shih-Huang Chan; Chung-Liang Ho; David Sidransky; Nan-Haw Chow
Journal:  J Clin Oncol       Date:  2002-03-15       Impact factor: 44.544

Review 8.  The biology of Hodgkin's lymphoma.

Authors:  Ralf Küppers
Journal:  Nat Rev Cancer       Date:  2008-12-11       Impact factor: 60.716

9.  IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

Authors:  Xiang Li; Paul E Massa; Adedayo Hanidu; Gregory W Peet; Patrick Aro; Ann Savitt; Sheenah Mische; Jun Li; Kenneth B Marcu
Journal:  J Biol Chem       Date:  2002-09-06       Impact factor: 5.157

Review 10.  DNA methylation in cancer: too much, but also too little.

Authors:  Melanie Ehrlich
Journal:  Oncogene       Date:  2002-08-12       Impact factor: 9.867
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  9 in total

Review 1.  Studies of endogenous retroviruses reveal a continuing evolutionary saga.

Authors:  Jonathan P Stoye
Journal:  Nat Rev Microbiol       Date:  2012-05-08       Impact factor: 60.633

Review 2.  The cell survival pathways of the primordial RNA-DNA complex remain conserved in the extant genomes and may function as proto-oncogenes.

Authors:  J G Sinkovics
Journal:  Eur J Microbiol Immunol (Bp)       Date:  2015-03-26

3.  Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer.

Authors:  Tushar D Bhagat; Yiyu Zou; Shizheng Huang; Jihwan Park; Matthew B Palmer; Caroline Hu; Weijuan Li; Niraj Shenoy; Orsolya Giricz; Gaurav Choudhary; Yiting Yu; Yi-An Ko; María C Izquierdo; Ae Seo Deok Park; Nishanth Vallumsetla; Remi Laurence; Robert Lopez; Masako Suzuki; James Pullman; Justin Kaner; Benjamin Gartrell; A Ari Hakimi; John M Greally; Bharvin Patel; Karim Benhadji; Kith Pradhan; Amit Verma; Katalin Susztak
Journal:  J Biol Chem       Date:  2016-12-01       Impact factor: 5.157

Review 4.  Human endogenous retroviruses and cancer: causality and therapeutic possibilities.

Authors:  Christina S Mullins; Michael Linnebacher
Journal:  World J Gastroenterol       Date:  2012-11-14       Impact factor: 5.742

5.  Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.

Authors:  Stephan Kreher; M Amine Bouhlel; Pierre Cauchy; Björn Lamprecht; Shuang Li; Michael Grau; Franziska Hummel; Karl Köchert; Ioannis Anagnostopoulos; Korinna Jöhrens; Michael Hummel; John Hiscott; Sören-Sebastian Wenzel; Peter Lenz; Markus Schneider; Ralf Küppers; Claus Scheidereit; Maciej Giefing; Reiner Siebert; Klaus Rajewsky; Georg Lenz; Peter N Cockerill; Martin Janz; Bernd Dörken; Constanze Bonifer; Stephan Mathas
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-06       Impact factor: 11.205

6.  HERV-E-mediated modulation of PLA2G4A transcription in urothelial carcinoma.

Authors:  Darko Gosenca; Ute Gabriel; Annette Steidler; Jens Mayer; Olivia Diem; Philipp Erben; Alice Fabarius; Christine Leib-Mösch; Wolf-Karsten Hofmann; Wolfgang Seifarth
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

Review 7.  Endogenous retroviral promoter exaptation in human cancer.

Authors:  Artem Babaian; Dixie L Mager
Journal:  Mob DNA       Date:  2016-12-01

8.  Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.

Authors:  K D Wurster; F Hummel; J Richter; M Giefing; S Hartmann; M-L Hansmann; S Kreher; K Köchert; D Krappmann; W Klapper; M Hummel; S-S Wenzel; G Lenz; M Janz; B Dörken; R Siebert; S Mathas
Journal:  Leukemia       Date:  2016-08-19       Impact factor: 11.528

Review 9.  Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.

Authors:  James A McCubrey; Linda S Steelman; William H Chappell; Stephen L Abrams; Giuseppe Montalto; Melchiorre Cervello; Ferdinando Nicoletti; Paolo Fagone; Grazia Malaponte; Maria C Mazzarino; Saverio Candido; Massimo Libra; Jörg Bäsecke; Sanja Mijatovic; Danijela Maksimovic-Ivanic; Michele Milella; Agostino Tafuri; Lucio Cocco; Camilla Evangelisti; Francesca Chiarini; Alberto M Martelli
Journal:  Oncotarget       Date:  2012-09
  9 in total

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