Literature DB >> 20980593

S-nitrosylation of cyclin-dependent kinase 5 (cdk5) regulates its kinase activity and dendrite growth during neuronal development.

Peng Zhang1, Pei-Chun Yu, Anthony H K Tsang, Yu Chen, Amy K Y Fu, Wing-Yu Fu, Kenny K Chung, Nancy Y Ip.   

Abstract

Precise regulation of cyclin-dependent kinase 5 (Cdk5), a member of the cyclin-dependent kinase family, is critical for proper neuronal development and functions. Cdk5 is activated through its association with the neuron-specific activator p35 or p39. Nonetheless, how its kinase activity is regulated in neurons is not well understood. In this study, we found that Cdk5 activity is regulated by S-nitrosylation, a post-translational modification of protein that affects a plethora of neuronal functions. S-nitrosylation of Cdk5 occurs at Cys83, which is one of the critical amino acids within the ATP-binding pocket of the kinase. Upon S-nitrosylation, Cdk5 exhibits reduced kinase activity, whereas mutation of Cys83 to Ala on Cdk5 renders the kinase refractory to such inhibition. Importantly, S-nitrosylated Cdk5 can be detected in the mouse brain, and blocking the S-nitrosylation of Cdk5 in cultured hippocampal neurons enhances dendritic growth and branching. Together, our findings reveal an important role of S-nitrosylation in regulating Cdk5 kinase activity and dendrite growth in neurons during development.

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Year:  2010        PMID: 20980593      PMCID: PMC6634798          DOI: 10.1523/JNEUROSCI.3899-10.2010

Source DB:  PubMed          Journal:  J Neurosci        ISSN: 0270-6474            Impact factor:   6.167


  30 in total

Review 1.  Regulation by S-nitrosylation of protein post-translational modification.

Authors:  Douglas T Hess; Jonathan S Stamler
Journal:  J Biol Chem       Date:  2011-12-06       Impact factor: 5.157

2.  S-nitrosylation of Cdk5: potential implications in amyloid-β-related neurotoxicity in Alzheimer disease.

Authors:  Jing Qu; Tomohiro Nakamura; Emily A Holland; Scott R McKercher; Stuart A Lipton
Journal:  Prion       Date:  2012-08-09       Impact factor: 3.931

3.  S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by beta-amyloid peptide.

Authors:  Jing Qu; Tomohiro Nakamura; Gang Cao; Emily A Holland; Scott R McKercher; Stuart A Lipton
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-15       Impact factor: 11.205

Review 4.  Emerging role of protein-protein transnitrosylation in cell signaling pathways.

Authors:  Tomohiro Nakamura; Stuart A Lipton
Journal:  Antioxid Redox Signal       Date:  2012-07-09       Impact factor: 8.401

Review 5.  Aberrant protein s-nitrosylation in neurodegenerative diseases.

Authors:  Tomohiro Nakamura; Shichun Tu; Mohd Waseem Akhtar; Carmen R Sunico; Shu-Ichi Okamoto; Stuart A Lipton
Journal:  Neuron       Date:  2013-05-22       Impact factor: 17.173

Review 6.  The Role of Cdk5 in Alzheimer's Disease.

Authors:  Shu-Lei Liu; Chong Wang; Teng Jiang; Lan Tan; Ang Xing; Jin-Tai Yu
Journal:  Mol Neurobiol       Date:  2015-07-31       Impact factor: 5.590

Review 7.  Cdk5 activity in the brain - multiple paths of regulation.

Authors:  Kavita Shah; Debomoy K Lahiri
Journal:  J Cell Sci       Date:  2014-06-01       Impact factor: 5.285

8.  STAT3 regulation by S-nitrosylation: implication for inflammatory disease.

Authors:  Jinsu Kim; Je-Seong Won; Avtar K Singh; Anand K Sharma; Inderjit Singh
Journal:  Antioxid Redox Signal       Date:  2014-02-14       Impact factor: 8.401

9.  Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.

Authors:  Atsushi Saito; Yu Taniguchi; Sun-Hong Kim; Balakrishnan Selvakumar; Gabriel Perez; Michael D Ballinger; Xiaolei Zhu; James Sabra; Mariama Jallow; Priscilla Yan; Koki Ito; Shreenath Rajendran; Shinji Hirotsune; Anthony Wynshaw-Boris; Solomon H Snyder; Akira Sawa; Atsushi Kamiya
Journal:  Cereb Cortex       Date:  2017-08-01       Impact factor: 5.357

Review 10.  S-Nitrosylation in Alzheimer's disease.

Authors:  Qing-Fei Zhao; Jin-Tai Yu; Lan Tan
Journal:  Mol Neurobiol       Date:  2014-03-25       Impact factor: 5.590

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