BACKGROUND: There is a paucity of research evaluating the relation between vitamin D and recurrence of breast cancer after treatment. OBJECTIVE: This study was designed to evaluate the associations between circulating concentrations of 25-hydroxyvitamin D [25(OH)D] and dietary, supplemental, and total intake of vitamin D and recurrent or new breast cancer events within the Women's Healthy Eating and Living (WHEL) Study. DESIGN: A prospective cohort study design (n = 3085) was used to evaluate the relation between dietary, supplemental, and total vitamin D intake and recurrent breast cancer, and a nested case-control study with 512 matched pairs was used for analysis of the association between 25(OH)D and breast cancer recurrence. RESULTS: No relation between 25(OH)D and breast cancer recurrence was observed. Compared with women with serum concentrations of 25(OH)D ≥ 30 ng/mL, adjusted odds ratios (95% CI) for breast cancer recurrence were 1.14 (0.57, 2.31) for those with concentrations < 10 ng/mL, 1.00 (0.68-1.48) for concentrations ≥ 10 and < 20 ng/mL, and 1.05 (0.76, 1.47) for concentrations ≥ 20 and < 30 ng/mL. No significant associations were observed when analyses were stratified by pre- and postmenopausal status or for local, regional, or distant recurrence or death. Vitamin D intake was not related to breast cancer recurrence overall, although for premenopausal women there was a significant inverse association between dietary vitamin D intake and recurrence (P for trend = 0.02). CONCLUSION: These results do not provide support for a relation between concentrations of 25(OH)D after treatment and the recurrence of breast cancer. This trial is registered at clinicaltrials.gov for the WHEL Study as NCT00003787.
RCT Entities:
BACKGROUND: There is a paucity of research evaluating the relation between vitamin D and recurrence of breast cancer after treatment. OBJECTIVE: This study was designed to evaluate the associations between circulating concentrations of 25-hydroxyvitamin D [25(OH)D] and dietary, supplemental, and total intake of vitamin D and recurrent or new breast cancer events within the Women's Healthy Eating and Living (WHEL) Study. DESIGN: A prospective cohort study design (n = 3085) was used to evaluate the relation between dietary, supplemental, and total vitamin D intake and recurrent breast cancer, and a nested case-control study with 512 matched pairs was used for analysis of the association between 25(OH)D and breast cancer recurrence. RESULTS: No relation between 25(OH)D and breast cancer recurrence was observed. Compared with women with serum concentrations of 25(OH)D ≥ 30 ng/mL, adjusted odds ratios (95% CI) for breast cancer recurrence were 1.14 (0.57, 2.31) for those with concentrations < 10 ng/mL, 1.00 (0.68-1.48) for concentrations ≥ 10 and < 20 ng/mL, and 1.05 (0.76, 1.47) for concentrations ≥ 20 and < 30 ng/mL. No significant associations were observed when analyses were stratified by pre- and postmenopausal status or for local, regional, or distant recurrence or death. Vitamin D intake was not related to breast cancer recurrence overall, although for premenopausal women there was a significant inverse association between dietary vitamin D intake and recurrence (P for trend = 0.02). CONCLUSION: These results do not provide support for a relation between concentrations of 25(OH)D after treatment and the recurrence of breast cancer. This trial is registered at clinicaltrials.gov for the WHEL Study as NCT00003787.
Authors: Cedric F Garland; Edward D Gorham; Sharif B Mohr; William B Grant; Edward L Giovannucci; Martin Lipkin; Harold Newmark; Michael F Holick; Frank C Garland Journal: J Steroid Biochem Mol Biol Date: 2007-03 Impact factor: 4.292
Authors: Julia A Knight; Maia Lesosky; Heidi Barnett; Janet M Raboud; Reinhold Vieth Journal: Cancer Epidemiol Biomarkers Prev Date: 2007-03 Impact factor: 4.254
Authors: Edward Giovannucci; Yan Liu; Eric B Rimm; Bruce W Hollis; Charles S Fuchs; Meir J Stampfer; Walter C Willett Journal: J Natl Cancer Inst Date: 2006-04-05 Impact factor: 13.506
Authors: Joan M Lappe; Dianne Travers-Gustafson; K Michael Davies; Robert R Recker; Robert P Heaney Journal: Am J Clin Nutr Date: 2007-06 Impact factor: 7.045
Authors: John P Pierce; Loki Natarajan; Bette J Caan; Barbara A Parker; E Robert Greenberg; Shirley W Flatt; Cheryl L Rock; Sheila Kealey; Wael K Al-Delaimy; Wayne A Bardwell; Robert W Carlson; Jennifer A Emond; Susan Faerber; Ellen B Gold; Richard A Hajek; Kathryn Hollenbach; Lovell A Jones; Njeri Karanja; Lisa Madlensky; James Marshall; Vicky A Newman; Cheryl Ritenbaugh; Cynthia A Thomson; Linda Wasserman; Marcia L Stefanick Journal: JAMA Date: 2007-07-18 Impact factor: 56.272
Authors: María Elena Martínez; Elizabeth T Jacobs; John A Baron; James R Marshall; Tim Byers Journal: J Natl Cancer Inst Date: 2012-04-25 Impact factor: 13.506
Authors: Marian L Neuhouser; JoAnn E Manson; Amy Millen; Mary Pettinger; Karen Margolis; Elizabeth T Jacobs; James M Shikany; Mara Vitolins; Lucile Adams-Campbell; Simin Liu; Erin LeBlanc; Karen C Johnson; Jean Wactawski-Wende Journal: Am J Epidemiol Date: 2012-02-22 Impact factor: 4.897
Authors: Elizabeth T Jacobs; Cynthia A Thomson; Shirley W Flatt; Vicky A Newman; Cheryl L Rock; John P Pierce Journal: Nutr Cancer Date: 2013 Impact factor: 2.900
Authors: Fatimah M Yousef; Elizabeth T Jacobs; Paul T Kang; Iman A Hakim; Scott Going; Jehad M Yousef; Rajaa M Al-Raddadi; Taha A Kumosani; Cynthia A Thomson Journal: Am J Clin Nutr Date: 2013-05-22 Impact factor: 7.045