Qing Qiao1, Xiao-Jing Gu, Jing Xu, Tai-Di Zhong. 1. Department of Anesthesiology, SIR RUN RUN SHAW Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.
Abstract
OBJECTIVE: The aim of this research is to observe whether esmolol infusion as an adjunct to propofol can affect BIS index, reduce anesthetic dose and decrease emergence time. METHOD:Sixty ASA I-II patients, age 18-35, undergoing uterine dilatation and curettage surgery were studied. They were randomized into two groups. Before induction, patients in esmolol group (Group E) were received 1 mg/kg esmolol intravenously and followed by esmolol 150 microg x kg(-1) x min(-1) intravenous infusion; patients in group C received normal saline instead of esmolol. Fentanyl (1 microg/kg) and propofol (2 mg/kg) were used as induction drugs. The change of BIS index, heart rate and MAP during operation; total amount of propofol; time when patients opened eyes and time when patients reached the standard for discharge from hospital were recorded. RESULTS:BIS and heart rate of Group C at 1,2,3 minute after surgery started, increased significantly compared with the time after induction and those in Group E (P < 0.05). The time patients reached the score of discharging from hospital in Group C is longer than that in Group E (P < 0.05). CONCLUSION:Esmolol combined with propofol administering in minor ambulatory operations can control the increase of BIS index caused by surgical nociceptive stimulus. Meanwhile the combination could reduce the dose of sedatives and decrease anesthesia emergence time.
RCT Entities:
OBJECTIVE: The aim of this research is to observe whether esmolol infusion as an adjunct to propofol can affect BIS index, reduce anesthetic dose and decrease emergence time. METHOD: Sixty ASA I-II patients, age 18-35, undergoing uterine dilatation and curettage surgery were studied. They were randomized into two groups. Before induction, patients in esmolol group (Group E) were received 1 mg/kg esmolol intravenously and followed by esmolol 150 microg x kg(-1) x min(-1) intravenous infusion; patients in group C received normal saline instead of esmolol. Fentanyl (1 microg/kg) and propofol (2 mg/kg) were used as induction drugs. The change of BIS index, heart rate and MAP during operation; total amount of propofol; time when patients opened eyes and time when patients reached the standard for discharge from hospital were recorded. RESULTS: BIS and heart rate of Group C at 1,2,3 minute after surgery started, increased significantly compared with the time after induction and those in Group E (P < 0.05). The time patients reached the score of discharging from hospital in Group C is longer than that in Group E (P < 0.05). CONCLUSION:Esmolol combined with propofol administering in minor ambulatory operations can control the increase of BIS index caused by surgical nociceptive stimulus. Meanwhile the combination could reduce the dose of sedatives and decrease anesthesia emergence time.