Literature DB >> 20977412

Targeting thioredoxin reductase: anticancer agents and chemopreventive compounds.

H H Zeng1, L H Wang.   

Abstract

Thioredoxin reductase plays a critical role in the regulation of cancer cell apoptosis, making it an attractive target for the design of new anticancer drugs. Several classes of compounds have been considered as potential antitumor or chemopreventive agents; most of them apparently interact with thioredoxin reductase's C-terminal redox center.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20977412     DOI： 10.2174/157340610793358864

Source DB:  PubMed          Journal:  Med Chem        ISSN： 1573-4064            Impact factor:   2.745


  3 in total

1.  Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model.

Authors:  Suo-Fu Ye; Jian Li; Shuang-Min Ji; Hui-Hui Zeng; Wei Lu
Journal:  Acta Pharmacol Sin       Date:  2016-12-05       Impact factor: 6.150

2.  Thioredoxin reductase is inhibited by the carbamoylating activity of the anticancer sulfonylhydrazine drug laromustine.

Authors:  Kevin P Rice; Edmund J Klinkerch; Scott A Gerber; Tyler R Schleicher; Tara J Kraus; Christopher M Buros
Journal:  Mol Cell Biochem       Date:  2012-08-05       Impact factor: 3.396

3.  Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine.

Authors:  Brian Cunniff; Gregg W Snider; Nicholas Fredette; Jason Stumpff; Robert J Hondal; Nicholas H Heintz
Journal:  Redox Biol       Date:  2014-02-19       Impact factor: 11.799
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.