Literature DB >> 20975779

KIF6 p.Trp719Arg Testing to Assess Risk of Coronary Artery Disease and/or Statin Response.

Diane Allingham-Hawkins1, Andrew Lea, Susan Levine.   

Abstract

Coronary artery disease (CAD) is a leading cause of death worldwide and in the United States it is responsible for more than 500,000 deaths each year. Genome-wide association studies (GWAS) have revealed connections between a number of common single nucleotide polymorphisms (SNPs) and CAD and other cardiovascular diseases. The p.Trp719Arg SNP in the kinesin-like family 6 (KIF6) gene has recently been reported as a potential risk factor for CAD as well as a predictor of response to statin therapy.

Entities:  

Year:  2010        PMID： 20975779      PMCID： PMC2959200.1          DOI： 10.1371/currents.RRN1191

Source DB:  PubMed          Journal:  PLoS Curr        ISSN： 2157-3999


  10 in total

1.  Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study.

Authors:  Alanna C Morrison; Lance A Bare; Lloyd E Chambless; Stephen G Ellis; Mary Malloy; John P Kane; James S Pankow; James J Devlin; James T Willerson; Eric Boerwinkle
Journal:  Am J Epidemiol       Date:  2007-04-18       Impact factor: 4.897

2.  Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.

Authors:  Olga A Iakoubova; Carmen H Tong; Charles M Rowland; Todd G Kirchgessner; Bradford A Young; Andre R Arellano; Dov Shiffman; Marc S Sabatine; Hannia Campos; Christopher J Packard; Marc A Pfeffer; Thomas J White; Eugene Braunwald; James Shepherd; James J Devlin; Frank M Sacks
Journal:  J Am Coll Cardiol       Date:  2008-01-29       Impact factor: 24.094

3.  Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study.

Authors:  Alexandre F R Stewart; Sonny Dandona; Li Chen; Olivia Assogba; Melanie Belanger; Gwen Ewart; Rosemary LaRose; Heather Doelle; Kathryn Williams; George A Wells; Ruth McPherson; Robert Roberts
Journal:  J Am Coll Cardiol       Date:  2009-04-21       Impact factor: 24.094

Review 4.  Genetics of coronary artery disease.

Authors:  Kiran Musunuru; Sekar Kathiresan
Journal:  Annu Rev Genomics Hum Genet       Date:  2010       Impact factor: 8.929

Review 5.  Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants.

Authors:  Kausik K Ray; Sreenivasa Rao Kondapally Seshasai; Sebhat Erqou; Peter Sever; J Wouter Jukema; Ian Ford; Naveed Sattar
Journal:  Arch Intern Med       Date:  2010-06-28

6.  Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial.

Authors:  Dov Shiffman; Marc S Sabatine; Judy Z Louie; Todd G Kirchgessner; Olga A Iakoubova; Hannia Campos; James J Devlin; Frank M Sacks
Journal:  Am J Cardiol       Date:  2010-03-20       Impact factor: 2.778

7.  Five common gene variants identify elevated genetic risk for coronary heart disease.

Authors:  Lance A Bare; Alanna C Morrison; Charles M Rowland; Dov Shiffman; May M Luke; Olga A Iakoubova; John P Kane; Mary J Malloy; Stephen G Ellis; James S Pankow; James T Willerson; James J Devlin; Eric Boerwinkle
Journal:  Genet Med       Date:  2007-10       Impact factor: 8.822

8.  A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.

Authors:  Dov Shiffman; Daniel I Chasman; Robert Y L Zee; Olga A Iakoubova; Judy Z Louie; James J Devlin; Paul M Ridker
Journal:  J Am Coll Cardiol       Date:  2008-01-29       Impact factor: 24.094

9.  Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.

Authors:  Olga A Iakoubova; Marc S Sabatine; Charles M Rowland; Carmen H Tong; Joseph J Catanese; Koustubh Ranade; Katy L Simonsen; Todd G Kirchgessner; Christopher P Cannon; James J Devlin; Eugene Braunwald
Journal:  J Am Coll Cardiol       Date:  2008-01-29       Impact factor: 24.094

10.  KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study.

Authors:  Olga A Iakoubova; Michele Robertson; Carmen H Tong; Charles M Rowland; Joseph J Catanese; Gerard J Blauw; J W Jukema; Michael B Murphy; James J Devlin; Ian Ford; James Shepherd
Journal:  Eur J Cardiovasc Prev Rehabil       Date:  2010-08
  10 in total
  1 in total

1.  Statin pharmacogenomics: opportunities to improve patient outcomes and healthcare costs with genetic testing.

Authors:  William J Canestaro; David G Brooks; Donald Chaplin; Niteesh K Choudhry; Elizabeth Lawler; Lori Martell; Troyen Brennan; E Robert Wassman
Journal:  J Pers Med       Date:  2012-10-17
  1 in total

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