| Literature DB >> 20974960 |
Francesca Turroni1, Francesca Bottacini, Elena Foroni, Imke Mulder, Jae-Han Kim, Aldert Zomer, Borja Sánchez, Alessandro Bidossi, Alberto Ferrarini, Vanessa Giubellini, Massimo Delledonne, Bernard Henrissat, Pedro Coutinho, Marco Oggioni, Gerald F Fitzgerald, David Mills, Abelardo Margolles, Denise Kelly, Douwe van Sinderen, Marco Ventura.
Abstract
The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.Entities:
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Year: 2010 PMID： 20974960 PMCID： PMC2984195 DOI： 10.1073/pnas.1011100107
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205