A Shin1, S Park2, H R Shin3, E-H Park2, S K Park4, J-K Oh5, M-K Lim5, B Y Choi6, M Boniol7, P Boffetta7. 1. Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management. 2. Cancer Registration and Statistics Branch, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang-si, Korea. 3. Cancer Registration and Statistics Branch, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang-si, Korea; Data Analysis and Interpretation Group, Biostatistics and Epidemiology Cluster, International Agency for Research on Cancer, Lyon, France. Electronic address: shinhr@iarc.fr. 4. Department of Preventive Medicine; Cancer Research Institute; Institute of Health Policy and Management, Seoul National University College of Medicine, Seoul. 5. Cancer Risk Appraisal and Prevention Branch, National Cancer Information Center, National Cancer Center, Goyang-si. 6. Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea. 7. Data Analysis and Interpretation Group, Biostatistics and Epidemiology Cluster, International Agency for Research on Cancer, Lyon, France.
Abstract
BACKGROUND: A number of infectious agents have been classified as human carcinogens. The purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the Korean population. MATERIALS AND METHODS: The population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly Korean studies and national data on cancer incidence and mortality for the year 2007. RESULTS: The fractions of all cancers attributable to infection were 25.1% and 16.8% for cancer incidence in men and women, and 25.8% and 22.7% of cancer mortality in men and women, respectively. Among infection-related cancers, Helicobacter pylori was responsible for 56.5% of cases and 45.1% of deaths, followed by hepatitis B virus (HBV) (23.9% of cases and 37.5% of deaths) and human papillomavirus (HPV) (11.3% of cases and 6% of deaths) and then by hepatitis C virus (HCV) (6% of cases and 9% of deaths). Over 97% of infection-related cancers were attributable to infection with H. pylori, HBV, HCV and HPV. CONCLUSION: Up to one-quarter of cancer cases and deaths would be preventable through appropriate control of infectious agents in Korea.
BACKGROUND: A number of infectious agents have been classified as human carcinogens. The purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the Korean population. MATERIALS AND METHODS: The population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly Korean studies and national data on cancer incidence and mortality for the year 2007. RESULTS: The fractions of all cancers attributable to infection were 25.1% and 16.8% for cancer incidence in men and women, and 25.8% and 22.7% of cancer mortality in men and women, respectively. Among infection-related cancers, Helicobacter pylori was responsible for 56.5% of cases and 45.1% of deaths, followed by hepatitis B virus (HBV) (23.9% of cases and 37.5% of deaths) and human papillomavirus (HPV) (11.3% of cases and 6% of deaths) and then by hepatitis C virus (HCV) (6% of cases and 9% of deaths). Over 97% of infection-related cancers were attributable to infection with H. pylori, HBV, HCV and HPV. CONCLUSION: Up to one-quarter of cancer cases and deaths would be preventable through appropriate control of infectious agents in Korea.
Authors: J B Wang; Y Jiang; H Liang; P Li; H J Xiao; J Ji; W Xiang; J F Shi; Y G Fan; L Li; D Wang; S S Deng; W Q Chen; W Q Wei; Y L Qiao; P Boffetta Journal: Ann Oncol Date: 2012-06-11 Impact factor: 32.976
Authors: Dongwoo Kim; Seok-Jun Yoon; Young-Hoon Gong; Young Ae Kim; Hye-Young Seo; Jihyun Yoon; A-Rim Kim Journal: J Prev Med Public Health Date: 2015-07-20