OBJECTIVE: This study was undertaken to determine whether there is familial aggregation of hyperemesis gravidarum (HG), making it a disease amenable to genetic study. STUDY DESIGN: Cases with severe nausea and vomiting in a singleton pregnancy treated with intravenous hydration and unaffected friend controls completed a survey regarding family history. RESULTS: Sisters of women with HG have a significantly increased risk of having HG themselves (odds ratio, 17.3; P = .005). Cases have a significantly increased risk of having a mother with severe nausea and vomiting; 33% of cases reported an affected mother compared to 7.7% of controls (P < .0001). Cases reported a similar frequency of affected second-degree maternal and paternal relatives (18% maternal lineage, 23% paternal lineage). CONCLUSION: There is familial aggregation of HG. This study provides strong evidence for a genetic component to HG. Identification of the predisposing gene(s) may determine the cause of this poorly understood disease of pregnancy.
OBJECTIVE: This study was undertaken to determine whether there is familial aggregation of hyperemesis gravidarum (HG), making it a disease amenable to genetic study. STUDY DESIGN: Cases with severe nausea and vomiting in a singleton pregnancy treated with intravenous hydration and unaffected friend controls completed a survey regarding family history. RESULTS: Sisters of women with HG have a significantly increased risk of having HG themselves (odds ratio, 17.3; P = .005). Cases have a significantly increased risk of having a mother with severe nausea and vomiting; 33% of cases reported an affected mother compared to 7.7% of controls (P < .0001). Cases reported a similar frequency of affected second-degree maternal and paternal relatives (18% maternal lineage, 23% paternal lineage). CONCLUSION: There is familial aggregation of HG. This study provides strong evidence for a genetic component to HG. Identification of the predisposing gene(s) may determine the cause of this poorly understood disease of pregnancy.
Authors: P Rodien; C Brémont; M L Sanson; J Parma; J Van Sande; S Costagliola; J P Luton; G Vassart; L Duprez Journal: N Engl J Med Date: 1998-12-17 Impact factor: 91.245
Authors: Joan Christodoulou-Smith; Jeffrey I Gold; Roberto Romero; Thomas M Goodwin; Kimber W Macgibbon; Patrick M Mullin; Marlena S Fejzo Journal: J Matern Fetal Neonatal Med Date: 2011-06-03
Authors: Marlena S Fejzo; Chunyu Ching; Frederic P Schoenberg; Kimber Macgibbon; Roberto Romero; T Murphy Goodwin; Patrick M Mullin Journal: J Matern Fetal Neonatal Med Date: 2011-11-24
Authors: Marlena Schoenberg Fejzo; Ronny Myhre; Lucía Colodro-Conde; Kimber W MacGibbon; Janet S Sinsheimer; M V Prasad Linga Reddy; Päivi Pajukanta; Dale R Nyholt; Margaret J Wright; Nicholas G Martin; Stephanie M Engel; Sarah E Medland; Per Magnus; Patrick M Mullin Journal: Mol Cell Endocrinol Date: 2016-09-20 Impact factor: 4.369