Literature DB >> 20970332

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria.

Stephen Hanessian1, Kandasamy Pachamuthu, Janek Szychowski, Alexandre Giguère, Eric E Swayze, Michael T Migawa, Boris François, Jiro Kondo, Eric Westhof.   

Abstract

Incorporation of an hydrophobic (phenethylamino)ethyl ether at C2″ of N1-(HABA)-3',4'-dideoxyparomomycin led to a novel analog with an excellent antibacterial profile against a host of resistant bacteria.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20970332     DOI： 10.1016/j.bmcl.2010.09.084

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes.

Authors:  Ido M Herzog; Keith D Green; Yifat Berkov-Zrihen; Mark Feldman; Roee R Vidavski; Anat Eldar-Boock; Ronit Satchi-Fainaro; Avigdor Eldar; Sylvie Garneau-Tsodikova; Micha Fridman
Journal:  Angew Chem Int Ed Engl       Date:  2012-04-12       Impact factor: 15.336

2.  A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription.

Authors:  Indrajit Das; Jérôme Désiré; Dinesh Manvar; Isabelle Baussanne; Virendra N Pandey; Jean-Luc Décout
Journal:  J Med Chem       Date:  2012-06-22       Impact factor: 7.446

3.  Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues.

Authors:  Janek Szychowski; Jiro Kondo; Omar Zahr; Karine Auclair; Eric Westhof; Stephen Hanessian; Jeffrey W Keillor
Journal:  ChemMedChem       Date:  2011-09-08       Impact factor: 3.466

4.  A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides.

Authors:  Nishad Thamban Chandrika; Sylvie Garneau-Tsodikova
Journal:  Medchemcomm       Date:  2015-11-19       Impact factor: 3.597

5.  Antifungal Amphiphilic Aminoglycosides.

Authors:  C-W T Chang; J Y Takemoto
Journal:  Medchemcomm       Date:  2014-08-01       Impact factor: 3.597

6.  Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue.

Authors:  Stephen Hanessian; Alexandre Giguère; Justyna Grzyb; Juan Pablo Maianti; Oscar M Saavedra; James B Aggen; Martin S Linsell; Adam A Goldblum; Darin J Hildebrandt; Timothy R Kane; Paola Dozzo; Micah J Gliedt; Rowena D Matias; Lee Ann Feeney; Eliana S Armstrong
Journal:  ACS Med Chem Lett       Date:  2011-09-29       Impact factor: 4.345

Review 7.  Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections.

Authors:  Kristin J Labby; Sylvie Garneau-Tsodikova
Journal:  Future Med Chem       Date:  2013-07       Impact factor: 3.808

8.  Synthesis and Bioactivities of Kanamycin B-Derived Cationic Amphiphiles.

Authors:  Marina Y Fosso; Sanjib K Shrestha; Keith D Green; Sylvie Garneau-Tsodikova
Journal:  J Med Chem       Date:  2015-12-01       Impact factor: 7.446

9.  Asymmetric stereodivergent strategy towards aminocyclitols.

Authors:  Barry M Trost; Sushant Malhotra
Journal:  Chemistry       Date:  2014-05-28       Impact factor: 5.236

Review 10.  Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance.

Authors:  Kun Shi; Shane J Caldwell; Desiree H Fong; Albert M Berghuis
Journal:  Front Cell Infect Microbiol       Date:  2013-06-25       Impact factor: 5.293
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