Caloric restriction and longevity: effects of reduced body temperature.

Caloric restriction (CR) causes a reduction in body temperature (T(b)) which is suggested to contribute to changes that increase lifespan. Moreover, low T(b) has been shown to improve health and longevity independent of CR. In this review we examine the connections between CR, T(b) and mechanisms that influence longevity and ageing. Recent findings regarding the overlapping mechanisms of CR and T(b) that benefit longevity are discussed, including changes in body composition, hormone regulation, and gene expression, as well as reductions in low-level inflammation and reactive oxygen species-induced molecular damage. This information is summarized in a model describing how CR and low T(b), both synergistically and independently, increase lifespan. Moreover, the nascent notion that the rate of ageing may be pre-programmed in response to environmental influences at critical periods of early development is also considered. Based on current evidence, it is concluded that low T(b) plays an integral role in mediating the effects of CR on health and longevity, and that low T(b) may exert independent biological changes that increase lifespan. Our understanding of the overlap between CR- and T(b)-mediated longevity remains incomplete and should be explored in future research.