| Literature DB >> 20969927 |
Khitam Muhsen1, Gabriel Chodick, Sophy Goren, Varda Shalev, Dani Cohen.
Abstract
We examined the uptake of rotavirus vaccine and its effectiveness in preventing acute gastroenteritis (AGE) in the community. Data on rotavirus vaccines purchases and AGE were extracted from the computerized database of a large health maintenance organization in Israel. The incidence of AGE requiring a physician visit during 2008-09 rotavirus season among vaccinated and non-vaccinated children were compared, and vaccine effectiveness was calculated as: (1-Relative Risk)×100. During the study period, the uptake of rotavirus vaccine (mostly monovalent) reached 55.1% (N=19,108) of the studied cohort. The risk of AGE requiring a physician visit was 23.2% and 46.4% among vaccinated and unvaccinated children, respectively, yielding an effectiveness of 50.1% (95% CI: 47.5%, 52.6%). Rotavirus monovalent vaccine was highly effective in preventing AGE in the community.Entities:
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Year: 2010 PMID： 20969927 DOI： 10.1016/j.vaccine.2010.10.010
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641