| Literature DB >> 20969924 |
Juan A Moreno-Cid1, Maribel Jiménez, Sylvie Cornelie, Ricardo Molina, Pedro Alarcón, Marie-Noelle Lacroix, Rocío Pinal, Sarah Delacour, Javier Lucientes, Mario Canales, José M Pérez de la Lastra, Margarita Villar, José de la Fuente.
Abstract
The control of arthropod vectors of pathogens that affect human and animal health is important for the eradication of vector-borne diseases. Recent evidences showed a reduction in the survival and/or fertility of mosquitoes, sand flies and poultry red mites fed in vitro with antibodies against the recombinant Aedes albopictus akirin. These experiments were the first step toward the development of a multi-target arthropod vaccine. In this study, we showed that the oviposition of A. albopictus and Phlebotomus perniciosus fed on mice vaccinated with recombinant A. albopictus akirin was reduced by 17% and 31%, respectively when compared to controls. However, Aedes aegypti mosquitoes were not affected after feeding on vaccinated mice. These results showed that recombinant A. albopictus akirin could be used to vaccinate hosts for the control of mosquito and sand fly infestations and suggested new experiments to develop improved vaccine formulations.Entities:
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Year: 2010 PMID： 20969924 DOI： 10.1016/j.vaccine.2010.10.011
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641