BACKGROUND: Microarray experiments have become very popular in life science research. However, if such experiments are only considered independently, the possibilities for analysis and interpretation of many life science phenomena are reduced. The accumulation of publicly available data provides biomedical researchers with a valuable opportunity to either discover new phenomena or improve the interpretation and validation of other phenomena that partially understood or well known. This can only be achieved by intelligently exploiting this rich mine of information. DESCRIPTION: Considering that technologies like microarrays remain prohibitively expensive for researchers with limited means to order their own experimental chips, it would be beneficial to re-use previously published microarray data. For certain researchers interested in finding gene groups (requiring many replicates), there is a great need for tools to help them to select appropriate datasets for analysis. These tools may be effective, if and only if, they are able to re-use previously deposited experiments or to create new experiments not initially envisioned by the depositors. However, the generation of new experiments requires that all published microarray data be completely annotated, which is not currently the case. Thus, we propose the PathEx approach. CONCLUSION: This paper presents PathEx, a human-focused web solution built around a two-component system: one database component, enriched with relevant biological information (expression array, omics data, literature) from different sources, and another component comprising sophisticated web interfaces that allow users to perform complex dataset building queries on the contents integrated into the PathEx database.
BACKGROUND: Microarray experiments have become very popular in life science research. However, if such experiments are only considered independently, the possibilities for analysis and interpretation of many life science phenomena are reduced. The accumulation of publicly available data provides biomedical researchers with a valuable opportunity to either discover new phenomena or improve the interpretation and validation of other phenomena that partially understood or well known. This can only be achieved by intelligently exploiting this rich mine of information. DESCRIPTION: Considering that technologies like microarrays remain prohibitively expensive for researchers with limited means to order their own experimental chips, it would be beneficial to re-use previously published microarray data. For certain researchers interested in finding gene groups (requiring many replicates), there is a great need for tools to help them to select appropriate datasets for analysis. These tools may be effective, if and only if, they are able to re-use previously deposited experiments or to create new experiments not initially envisioned by the depositors. However, the generation of new experiments requires that all published microarray data be completely annotated, which is not currently the case. Thus, we propose the PathEx approach. CONCLUSION: This paper presents PathEx, a human-focused web solution built around a two-component system: one database component, enriched with relevant biological information (expression array, omics data, literature) from different sources, and another component comprising sophisticated web interfaces that allow users to perform complex dataset building queries on the contents integrated into the PathEx database.
Authors: Hongfang Liu; Barry R Zeeberg; Gang Qu; A Gunes Koru; Alessandro Ferrucci; Ari Kahn; Michael C Ryan; Antej Nuhanovic; Peter J Munson; William C Reinhold; David W Kane; John N Weinstein Journal: Bioinformatics Date: 2007-07-27 Impact factor: 6.937
Authors: Manhong Dai; Pinglang Wang; Andrew D Boyd; Georgi Kostov; Brian Athey; Edward G Jones; William E Bunney; Richard M Myers; Terry P Speed; Huda Akil; Stanley J Watson; Fan Meng Journal: Nucleic Acids Res Date: 2005-11-10 Impact factor: 16.971
Authors: E Birney; D Andrews; M Caccamo; Y Chen; L Clarke; G Coates; T Cox; F Cunningham; V Curwen; T Cutts; T Down; R Durbin; X M Fernandez-Suarez; P Flicek; S Gräf; M Hammond; J Herrero; K Howe; V Iyer; K Jekosch; A Kähäri; A Kasprzyk; D Keefe; F Kokocinski; E Kulesha; D London; I Longden; C Melsopp; P Meidl; B Overduin; A Parker; G Proctor; A Prlic; M Rae; D Rios; S Redmond; M Schuster; I Sealy; S Searle; J Severin; G Slater; D Smedley; J Smith; A Stabenau; J Stalker; S Trevanion; A Ureta-Vidal; J Vogel; S White; C Woodwark; T J P Hubbard Journal: Nucleic Acids Res Date: 2006-01-01 Impact factor: 16.971
Authors: Tim F Rayner; Philippe Rocca-Serra; Paul T Spellman; Helen C Causton; Anna Farne; Ele Holloway; Rafael A Irizarry; Junmin Liu; Donald S Maier; Michael Miller; Kjell Petersen; John Quackenbush; Gavin Sherlock; Christian J Stoeckert; Joseph White; Patricia L Whetzel; Farrell Wymore; Helen Parkinson; Ugis Sarkans; Catherine A Ball; Alvis Brazma Journal: BMC Bioinformatics Date: 2006-11-06 Impact factor: 3.169
Authors: H Parkinson; M Kapushesky; M Shojatalab; N Abeygunawardena; R Coulson; A Farne; E Holloway; N Kolesnykov; P Lilja; M Lukk; R Mani; T Rayner; A Sharma; E William; U Sarkans; A Brazma Journal: Nucleic Acids Res Date: 2006-11-28 Impact factor: 16.971
Authors: T J P Hubbard; B L Aken; K Beal; B Ballester; M Caccamo; Y Chen; L Clarke; G Coates; F Cunningham; T Cutts; T Down; S C Dyer; S Fitzgerald; J Fernandez-Banet; S Graf; S Haider; M Hammond; J Herrero; R Holland; K Howe; K Howe; N Johnson; A Kahari; D Keefe; F Kokocinski; E Kulesha; D Lawson; I Longden; C Melsopp; K Megy; P Meidl; B Ouverdin; A Parker; A Prlic; S Rice; D Rios; M Schuster; I Sealy; J Severin; G Slater; D Smedley; G Spudich; S Trevanion; A Vilella; J Vogel; S White; M Wood; T Cox; V Curwen; R Durbin; X M Fernandez-Suarez; P Flicek; A Kasprzyk; G Proctor; S Searle; J Smith; A Ureta-Vidal; E Birney Journal: Nucleic Acids Res Date: 2006-12-05 Impact factor: 16.971
Authors: P Flicek; B L Aken; K Beal; B Ballester; M Caccamo; Y Chen; L Clarke; G Coates; F Cunningham; T Cutts; T Down; S C Dyer; T Eyre; S Fitzgerald; J Fernandez-Banet; S Gräf; S Haider; M Hammond; R Holland; K L Howe; K Howe; N Johnson; A Jenkinson; A Kähäri; D Keefe; F Kokocinski; E Kulesha; D Lawson; I Longden; K Megy; P Meidl; B Overduin; A Parker; B Pritchard; A Prlic; S Rice; D Rios; M Schuster; I Sealy; G Slater; D Smedley; G Spudich; S Trevanion; A J Vilella; J Vogel; S White; M Wood; E Birney; T Cox; V Curwen; R Durbin; X M Fernandez-Suarez; J Herrero; T J P Hubbard; A Kasprzyk; G Proctor; J Smith; A Ureta-Vidal; S Searle Journal: Nucleic Acids Res Date: 2007-11-13 Impact factor: 16.971
Authors: Raphaël Helaers; Eric Bareke; Bertrand De Meulder; Michael Pierre; Sophie Depiereux; Naji Habra; Eric Depiereux Journal: BMC Res Notes Date: 2011-10-27
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