BACKGROUND: Endoscopic resection followed by radiotherapy as primary treatment for adenocarcinoma of the sinuses is emerging as an alternative to open resection. METHODS: A total of 44 patients primarily treated by an endoscopic approach followed by radiotherapy from 1992 to 2004 seen at our ENT-Department were analyzed for outcome and prognostic factors. RESULTS: Median follow-up was 61 months. Median follow-up of the patients alive at the end of the follow-up period was 100 months. For the 5-year follow-up, the overall survival, disease-specific survival, and recurrence-free survival were 63% (±7% SE), 82% (±6), and 60% (±8%), respectively. The overall survival, disease-specific survival, and recurrence-free survival after 100 months of follow-up were 53% (±8%), 72% (±9%), and 54% (±9%), respectively. Four factors significantly influenced the disease-specific survival. CONCLUSION: This study of a homogeneous cohort of patients with sinonasal adenocarcinoma treated by endoscopic resection and radiotherapy confirms that endoscopic resection is a valid alternative to open resection.
BACKGROUND: Endoscopic resection followed by radiotherapy as primary treatment for adenocarcinoma of the sinuses is emerging as an alternative to open resection. METHODS: A total of 44 patients primarily treated by an endoscopic approach followed by radiotherapy from 1992 to 2004 seen at our ENT-Department were analyzed for outcome and prognostic factors. RESULTS: Median follow-up was 61 months. Median follow-up of the patients alive at the end of the follow-up period was 100 months. For the 5-year follow-up, the overall survival, disease-specific survival, and recurrence-free survival were 63% (±7% SE), 82% (±6), and 60% (±8%), respectively. The overall survival, disease-specific survival, and recurrence-free survival after 100 months of follow-up were 53% (±8%), 72% (±9%), and 54% (±9%), respectively. Four factors significantly influenced the disease-specific survival. CONCLUSION: This study of a homogeneous cohort of patients with sinonasal adenocarcinoma treated by endoscopic resection and radiotherapy confirms that endoscopic resection is a valid alternative to open resection.
Authors: Antoine Digonnet; Marc Hamoir; Guy Andry; Vincent Vander Poorten; Missak Haigentz; Johannes A Langendijk; Remco de Bree; Michael L Hinni; William M Mendenhall; Vinidh Paleri; Alessandra Rinaldo; Jochen A Werner; Robert P Takes; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2012-10-26 Impact factor: 2.503
Authors: N Oker; P Lang; D Bresson; B George; J-P Guichard; M Wassef; E Sauvaget; S Froelich; R Kania; P Herman Journal: Eur Arch Otorhinolaryngol Date: 2014-04-16 Impact factor: 2.503
Authors: Laura Van Gerven; Zhen Qian; Anastasiya Starovoyt; Mark Jorissen; Jeroen Meulemans; Johannes van Loon; Steven De Vleeschouwer; Julie Lambert; Marie Bex; Vincent Vander Poorten Journal: Front Oncol Date: 2021-05-07 Impact factor: 6.244