Literature DB >> 20967472

What can Drosophila teach us about iron-accumulation neurodegenerative disorders?

Uriya Bekenstein1, Sebastian Kadener.   

Abstract

The present review focuses on the development and use of Drosophila for modeling neurodegenerative disorders that involve iron accumulation, in particular Friedrich's Ataxia (FRDA) and Neurodegeneration with Iron accumulation (NBIA). Several Drosophila models of such disorders have been introduced successfully in the last few years. Here we review these models and note on the feasibility and advantages of using fly models for understanding the molecular and cellular bases of these devastating diseases.

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Year:  2010        PMID： 20967472     DOI： 10.1007/s00702-010-0511-7

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  39 in total

1.  RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila.

Authors:  Peter R Anderson; Kim Kirby; Arthur J Hilliker; John P Phillips
Journal:  Hum Mol Genet       Date:  2005-10-03       Impact factor: 6.150

2.  Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity.

Authors:  Oleksandr Gakh; Sungjo Park; Gang Liu; Lee Macomber; James A Imlay; Gloria C Ferreira; Grazia Isaya
Journal:  Hum Mol Genet       Date:  2005-12-21       Impact factor: 6.150

Review 3.  Conditional mouse models for Friedreich ataxia, a neurodegenerative disorder associating cardiomyopathy.

Authors:  H Puccio
Journal:  Handb Exp Pharmacol       Date:  2007

4.  Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.

Authors:  Y Yang; Z Wu; Y M Kuo; B Zhou
Journal:  J Inherit Metab Dis       Date:  2005       Impact factor: 4.982

5.  Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration.

Authors:  Anil Rana; Erwin Seinen; Katarzyna Siudeja; Remco Muntendam; Balaji Srinivasan; Johannes J van der Want; Susan Hayflick; Dirk-Jan Reijngoud; Oliver Kayser; Ody C M Sibon
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-29       Impact factor: 11.205

6.  dfh is a Drosophila homolog of the Friedreich's ataxia disease gene.

Authors:  J Cañizares; J M Blanca; J A Navarro; E Monrós; F Palau; M D Moltó
Journal:  Gene       Date:  2000-10-03       Impact factor: 3.688

7.  Genetic suppression of polyglutamine toxicity in Drosophila.

Authors:  P Kazemi-Esfarjani; S Benzer
Journal:  Science       Date:  2000-03-10       Impact factor: 47.728

8.  Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation.

Authors:  Or Kakhlon; Hila Manning; William Breuer; Naomi Melamed-Book; Chunye Lu; Gino Cortopassi; Arnold Munnich; Z Ioav Cabantchik
Journal:  Blood       Date:  2008-09-16       Impact factor: 22.113

9.  Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer.

Authors:  Ulrika Schagerlöf; Hans Elmlund; Oleksandr Gakh; Gustav Nordlund; Hans Hebert; Martin Lindahl; Grazia Isaya; Salam Al-Karadaghi
Journal:  Biochemistry       Date:  2008-04-05       Impact factor: 3.162

10.  Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

Authors:  A H Brand; N Perrimon
Journal:  Development       Date:  1993-06       Impact factor: 6.868
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  1 in total

Review 1.  Iron absorption in Drosophila melanogaster.

Authors:  Konstantinos Mandilaras; Tharse Pathmanathan; Fanis Missirlis
Journal:  Nutrients       Date:  2013-05-17       Impact factor: 5.717
  1 in total

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