Azzrah Thobani1, Gerald A Fishman. 1. Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Abstract
PURPOSE: The purpose of this study was to determine if carbonic anhydrase inhibitors can restore their efficacy after a period of discontinued use in patients with cystic foveal lesions who demonstrated subsequent worsening in the extent of their foveal cysts after initially exhibiting a favorable response to treatment. METHODS: Retrospective chart review was conducted on all patients with retinitis pigmentosa or X-linked retinoschisis who were either currently on treatment or had been treated with carbonic anhydrase inhibitors for cystic macular lesions. A total of three patients were included in the study. RESULTS: All three patients exhibited a recurrence of their cystic macular lesions while on treatment with carbonic anhydrase inhibitors. After discontinuing treatment for a period of 1 month to 6 months, all patients showed a favorable response to retreatment as monitored with optical coherence tomography scans. CONCLUSION: The present study shows that patients who show signs of recurring macular cysts while still on treatment can have a favorable response when treatment is reinstated after a period of discontinued use of a carbonic anhydrase inhibitor.
PURPOSE: The purpose of this study was to determine if carbonic anhydrase inhibitors can restore their efficacy after a period of discontinued use in patients with cystic foveal lesions who demonstrated subsequent worsening in the extent of their foveal cysts after initially exhibiting a favorable response to treatment. METHODS: Retrospective chart review was conducted on all patients with retinitis pigmentosa or X-linked retinoschisis who were either currently on treatment or had been treated with carbonic anhydrase inhibitors for cystic macular lesions. A total of three patients were included in the study. RESULTS: All three patients exhibited a recurrence of their cystic macular lesions while on treatment with carbonic anhydrase inhibitors. After discontinuing treatment for a period of 1 month to 6 months, all patients showed a favorable response to retreatment as monitored with optical coherence tomography scans. CONCLUSION: The present study shows that patients who show signs of recurring macular cysts while still on treatment can have a favorable response when treatment is reinstated after a period of discontinued use of a carbonic anhydrase inhibitor.
Authors: Saloni Walia; Gerald A Fishman; Robert S Molday; Frank M Dyka; Nalin M Kumar; Mary A Ehlinger; Edwin M Stone Journal: Am J Ophthalmol Date: 2008-10-02 Impact factor: 5.258
Authors: Cyril G Eleftheriou; Carlo Corona; Shireen Khattak; Nazia M Alam; Elena Ivanova; Paola Bianchimano; Yang Liu; Duo Sun; Rupesh Singh; Julia C Batoki; Glen T Prusky; J Jason McAnany; Neal S Peachey; Carmelo Romano; Botir T Sagdullaev Journal: J Neurosci Date: 2022-07-29 Impact factor: 6.709
Authors: Brett G Jeffrey; Catherine A Cukras; Susan Vitale; Amy Turriff; Kristin Bowles; Paul A Sieving Journal: Transl Vis Sci Technol Date: 2014-10-03 Impact factor: 3.283
Authors: Lea D Bennett; Yi-Zhong Wang; Martin Klein; Mark E Pennesi; Thiran Jayasundera; David G Birch Journal: Invest Ophthalmol Vis Sci Date: 2016-02 Impact factor: 4.799