BACKGROUND: : The efficacy of repetitive transcranial magnetic stimulation (rTMS) has been poorly investigated in the long-term. The present follow-up study was aimed to assess the long-term efficacy and the discontinuation effects of rTMS in a sample of depressed bipolar patients. METHODS: : After the completion of an acute trial with augmentative, low-frequency, navigated rTMS, 11 drug-resistant depressed bipolar subjects (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition [Text Revision] criteria) entered a naturalistic follow-up with monthly evaluations through the Hamilton Depression Rating Scale and the Young Mania Rating Scale. RESULTS: : After 1 year of follow-up, results showed that the achievement of remission after acute rTMS was predictive of maintenance of response at 1 year. On the other hand, the absence of acute rTMS response predicted the absence of subsequent response in the long-term. CONCLUSIONS: : This first report on the long-term discontinuation effects after acute rTMS suggests that immediate remission is predictive of sustained benefit after 1 year. Larger controlled studies are needed to confirm present preliminary findings.
BACKGROUND: : The efficacy of repetitive transcranial magnetic stimulation (rTMS) has been poorly investigated in the long-term. The present follow-up study was aimed to assess the long-term efficacy and the discontinuation effects of rTMS in a sample of depressed bipolarpatients. METHODS: : After the completion of an acute trial with augmentative, low-frequency, navigated rTMS, 11 drug-resistant depressed bipolar subjects (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition [Text Revision] criteria) entered a naturalistic follow-up with monthly evaluations through the Hamilton Depression Rating Scale and the Young Mania Rating Scale. RESULTS: : After 1 year of follow-up, results showed that the achievement of remission after acute rTMS was predictive of maintenance of response at 1 year. On the other hand, the absence of acute rTMS response predicted the absence of subsequent response in the long-term. CONCLUSIONS: : This first report on the long-term discontinuation effects after acute rTMS suggests that immediate remission is predictive of sustained benefit after 1 year. Larger controlled studies are needed to confirm present preliminary findings.
Authors: Yechiel Levkovitz; Moshe Isserles; Frank Padberg; Sarah H Lisanby; Alexander Bystritsky; Guohua Xia; Aron Tendler; Zafiris J Daskalakis; Jaron L Winston; Pinhas Dannon; Hisham M Hafez; Irving M Reti; Oscar G Morales; Thomas E Schlaepfer; Eric Hollander; Joshua A Berman; Mustafa M Husain; Uzi Sofer; Ahava Stein; Shmulik Adler; Lisa Deutsch; Frederic Deutsch; Yiftach Roth; Mark S George; Abraham Zangen Journal: World Psychiatry Date: 2015-02 Impact factor: 49.548
Authors: Bernardo Dell'osso; Giulia Camuri; Filippo Castellano; Vittoria Vecchi; Matteo Benedetti; Sara Bortolussi; A Carlo Altamura Journal: Clin Pract Epidemiol Ment Health Date: 2011-10-26
Authors: Chiara Rapinesi; Francesco Saverio Bersani; Georgios D Kotzalidis; Claudio Imperatori; Antonio Del Casale; Simone Di Pietro; Vittoria R Ferri; Daniele Serata; Ruggero N Raccah; Abraham Zangen; Gloria Angeletti; Paolo Girardi Journal: Front Neurol Date: 2015-02-09 Impact factor: 4.003
Authors: Alexandra K Gold; Ana Claudia Ornelas; Patricia Cirillo; Marco Antonio Caldieraro; Antonio Egidio Nardi; Andrew A Nierenberg; Gustavo Kinrys Journal: Brain Behav Date: 2019-09-30 Impact factor: 2.708
Authors: Pedro Henrique da Costa Ferreira Pinto; Flavio Nigri; Egas Moniz Caparelli-Dáquer; Jucilana Dos Santos Viana Journal: Surg Neurol Int Date: 2019-07-05