BACKGROUND: Atrial fibrillation developing at the acute stage of myocardial infarction is associated with untoward clinical outcomes. The aim of this study was to determine correlations between early statin therapy and atrial fibrillation in acute myocardial infarction. METHODS: Patients (3396) with sinus rhythm developing acute myocardial infarction were enrolled in the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI). RESULTS: Atrial fibrillation developed in 7.0% of patients without and 3.9% of patients with early (≤48 h of admission) statin therapy (p<0.001). Multivariable analysis, including the propensity score for early statin treatment, showed that statin therapy was associated with reduced risk of atrial fibrillation (OR 0.64; 95% CI 0.45 to 0.92, p=0.017). Compared to patients without early statin therapy, the OR for atrial fibrillation were 0.72 (0.49 to 1.04, p=0.080), 0.52 (0.28 to 0.95, p=0.034) and 0.40 (0.18 to 0.92, p=0.030) in patients on conventional, intermediate and high doses respectively. CONCLUSIONS: This study is the first to document a correlation between early statin therapy and atrial fibrillation at the early stage of acute myocardial infarction.
BACKGROUND:Atrial fibrillation developing at the acute stage of myocardial infarction is associated with untoward clinical outcomes. The aim of this study was to determine correlations between early statin therapy and atrial fibrillation in acute myocardial infarction. METHODS:Patients (3396) with sinus rhythm developing acute myocardial infarction were enrolled in the French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI). RESULTS:Atrial fibrillation developed in 7.0% of patients without and 3.9% of patients with early (≤48 h of admission) statin therapy (p<0.001). Multivariable analysis, including the propensity score for early statin treatment, showed that statin therapy was associated with reduced risk of atrial fibrillation (OR 0.64; 95% CI 0.45 to 0.92, p=0.017). Compared to patients without early statin therapy, the OR for atrial fibrillation were 0.72 (0.49 to 1.04, p=0.080), 0.52 (0.28 to 0.95, p=0.034) and 0.40 (0.18 to 0.92, p=0.030) in patients on conventional, intermediate and high doses respectively. CONCLUSIONS: This study is the first to document a correlation between early statin therapy and atrial fibrillation at the early stage of acute myocardial infarction.
Authors: Keith A A Fox; Gordon Fitzgerald; Etienne Puymirat; Wei Huang; Kathryn Carruthers; Tabassome Simon; Pierre Coste; Jacques Monsegu; Philippe Gabriel Steg; Nicolas Danchin; Fred Anderson Journal: BMJ Open Date: 2014-02-21 Impact factor: 2.692
Authors: Kisa Hyde Congo; Adriana Belo; João Carvalho; David Neves; Rui Guerreiro; João António Pais; Diogo Brás; Mafalda Carrington; Bruno Piçarra; Ana Rita Santos; José Aguiar Journal: Arq Bras Cardiol Date: 2019-11 Impact factor: 2.000
Authors: Ana Catarina Pinho-Gomes; Svetlana Reilly; Ralf P Brandes; Barbara Casadei Journal: Antioxid Redox Signal Date: 2013-10-19 Impact factor: 8.401