Literature DB >> 2096498

Quinoline esters as potential antimalarial drugs: effect on relapses of Plasmodium cynomolgi infections in monkeys.

S K Puri1, G P Dutta.   

Abstract

Two compounds of the quinoline ester series, WR 197236 (6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline ) and WR 194905 (4-acetoxy-6-decyloxy-7-isopropoxy-3-methoxycarbonylquinoline++ +), exhibit anti-relapse activity against sporozoite-induced Plasmodium cynomolgi B infections in rhesus monkeys. Both the compounds have been found to be curative when given intramuscularly in 7 daily doses of 15 mg/kg, and no relapses were observed during the observation period of 120 d.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2096498     DOI： 10.1016/0035-9203(90)90066-n

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  15 in total

1.  Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones.

Authors:  Yiqun Zhang; W Armand Guiguemde; Martina Sigal; Fangyi Zhu; Michele C Connelly; Solomon Nwaka; R Kiplin Guy
Journal:  Bioorg Med Chem       Date:  2010-02-11       Impact factor: 3.641

2.  4(1H)-Quinolones with liver stage activity against Plasmodium berghei.

Authors:  Alexis N Lacrue; Fabián E Sáenz; R Matthew Cross; Kenneth O Udenze; Andrii Monastyrskyi; Steven Stein; Tina S Mutka; Roman Manetsch; Dennis E Kyle
Journal:  Antimicrob Agents Chemother       Date:  2012-11-05       Impact factor: 5.191

3.  4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities.

Authors:  Andrii Monastyrskyi; Dennis E Kyle; Roman Manetsch
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

4.  Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

Authors:  Yiqun Zhang; Julie A Clark; Michele C Connelly; Fangyi Zhu; Jaeki Min; W Armand Guiguemde; Anupam Pradhan; Lalitha Iyer; Anna Furimsky; Jason Gow; Toufan Parman; Farah El Mazouni; Margaret A Phillips; Dennis E Kyle; Jon Mirsalis; R Kiplin Guy
Journal:  J Med Chem       Date:  2012-04-18       Impact factor: 7.446

Review 5.  Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax.

Authors:  Brice Campo; Omar Vandal; David L Wesche; Jeremy N Burrows
Journal:  Pathog Glob Health       Date:  2015-04-18       Impact factor: 2.894

6.  Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.

Authors:  Raghupathi Neelarapu; Jordany R Maignan; Cynthia L Lichorowic; Andrii Monastyrskyi; Tina S Mutka; Alexis N LaCrue; Lynn D Blake; Debora Casandra; Sherwin Mashkouri; Jeremy N Burrows; Paul A Willis; Dennis E Kyle; Roman Manetsch
Journal:  J Med Chem       Date:  2018-02-09       Impact factor: 7.446

Review 7.  The hypnozoite and relapse in primate malaria.

Authors:  F B Cogswell
Journal:  Clin Microbiol Rev       Date:  1992-01       Impact factor: 26.132

8.  4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni.

Authors:  Fabián E Sáenz; Alexis N Lacrue; R Matthew Cross; Jordany R Maignan; Kenneth O Udenze; Roman Manetsch; Dennis E Kyle
Journal:  Antimicrob Agents Chemother       Date:  2013-09-30       Impact factor: 5.191

9.  Antimalarial quinolones: synthesis, potency, and mechanistic studies.

Authors:  Rolf W Winter; Jane X Kelly; Martin J Smilkstein; Rozalia Dodean; David Hinrichs; Michael K Riscoe
Journal:  Exp Parasitol       Date:  2007-11-07       Impact factor: 2.011

10.  Progress in the Optimization of 4(1H)-Quinolone Derivatives as Antimalarials Targeting the Erythrocytic, the Exoerythrocytic and the Transmitting Stages of the Malaria Parasite.

Authors:  Fabian Brockmeyer; Roman Manetsch
Journal:  Chimia (Aarau)       Date:  2017-04-26       Impact factor: 1.656
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.