OBJECTIVE: To assess the value of left ventricular (LV) dyssynchrony, using phase analysis of nuclear single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as independent predictor of cardiac events. METHODS: Phase analysis using Emory Cardiac Toolbox was applied on gated rest MPI scans to assess LV dyssynchrony in a total of 202 patients. Follow-up was obtained in 197 patients (97.5%). Major adverse cardiac events (MACE) (cardiac death and hospitalisation for any cardiac reasons, including worsening of heart failure, non-fatal myocardial infarction, unstable angina and coronary revascularisation) were determined using the Kaplan-Meier method. Cox proportional hazard regression was used to identify independent predictors of cardiac events. RESULTS: At a median follow-up of 3.2 ± 1.2 years, 41 patients had at least one event, including 5 cardiac deaths. LV dyssynchrony (n = 35) was associated with a significantly higher incidence of MACE (p<0.001) and proved to be an independent predictor of cardiac events. CONCLUSION: LV dyssynchrony assessed by phase analysis of gated SPECT-MPI is a strong predictor of MACE independent of other known predictors such as perfusion defects or decreased LV ejection fraction.
OBJECTIVE: To assess the value of left ventricular (LV) dyssynchrony, using phase analysis of nuclear single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as independent predictor of cardiac events. METHODS: Phase analysis using Emory Cardiac Toolbox was applied on gated rest MPI scans to assess LV dyssynchrony in a total of 202 patients. Follow-up was obtained in 197 patients (97.5%). Major adverse cardiac events (MACE) (cardiac death and hospitalisation for any cardiac reasons, including worsening of heart failure, non-fatal myocardial infarction, unstable angina and coronary revascularisation) were determined using the Kaplan-Meier method. Cox proportional hazard regression was used to identify independent predictors of cardiac events. RESULTS: At a median follow-up of 3.2 ± 1.2 years, 41 patients had at least one event, including 5 cardiac deaths. LV dyssynchrony (n = 35) was associated with a significantly higher incidence of MACE (p<0.001) and proved to be an independent predictor of cardiac events. CONCLUSION:LV dyssynchrony assessed by phase analysis of gated SPECT-MPI is a strong predictor of MACE independent of other known predictors such as perfusion defects or decreased LV ejection fraction.
Authors: Fadi G Hage; Himanshu Aggarwal; Kanan Patel; Ji Chen; Arnold F Jacobson; Jaekyeong Heo; Ali Ahmed; Ami E Iskandrian Journal: J Nucl Cardiol Date: 2013-10-30 Impact factor: 5.952
Authors: Paul L Hess; Linda K Shaw; Sreekanth Vemulapalli; Robert Pagnanelli; Christopher M O'Connor; Salvador Borges-Neto Journal: J Nucl Cardiol Date: 2015-05-21 Impact factor: 5.952
Authors: Matti J Kortelainen; Tuomas M Koivumäki; Marko J Vauhkonen; Marja K Hedman; Satu T J Kärkkäinen; Juanita Niño Quintero; Mikko A Hakulinen Journal: J Nucl Cardiol Date: 2017-03-16 Impact factor: 5.952