Literature DB >> 20961760

pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1.

Melania Capasso1, Thomas E DeCoursey, Martin J S Dyer.   

Abstract

Electrophysiological studies have implicated voltage-gated proton channels in several specific cellular contexts. In neutrophils, they mediate charge compensation that is associated with the oxidative burst of phagocytosis. Molecular characterization of the hydrogen voltage-gated channel 1 (HVCN1) has enabled identification of unanticipated and diverse functions: HVCN1 not only modulates signaling from the B-cell receptor following B-cell activation and histamine release from basophils, but also mediates pH-dependent activation of spermatozoa, as well as acid secretion by tracheal epithelium. The importance of HVCN1 in pH regulation during phagocytosis was established by surprising evidence that indicated its first-responder role. In this review, we discuss recent findings from a functional perspective, and the potential of HVCN1 as a therapeutic target for autoimmune and other diseases. Copyright Â
© 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20961760      PMCID： PMC3014425          DOI： 10.1016/j.tcb.2010.09.006

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


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