BACKGROUND: Patients with a solid organ transplant (SOTs) and hematopoietic stem cell or bone marrow transplants (HSC/BMTs) are at risk of contracting invasive fungal infections (IFIs). Data on the economic burden of IFIs in the United States are sparse. METHODS: We conducted a retrospective matched cohort study using the 2004-2005 Healthcare Cost and Utilization Project Nationwide Inpatient Sample. The IFI cohort included patients with ICD-9-CM codes indicating a transplant procedure and an IFI. Matched controls (transplant recipients without an IFI) were chosen based on age (10 year categories), sex, region, hospital type, year, and transplant type. Mortality, length of stay, and costs were reported overall, by transplant type, and by type of mycosis. RESULTS: Nine thousand eight hundred ninety-six patients underwent SOT, and 4661 underwent HSC/BMT. Of these, 80 (0.8%) SOT and 111 (2.4%) HSC/BMT patients had an IFI. Mean age was 41.8 years (SOT) and 37.8 years (HSC/BMT). Aspergillosis was the most common infection. Patients with an IFI had a 5-fold increase in mortality, an additional 19.2 hospital days, and $55,400 in excess costs compared with patients without an IFI. Excess mortality, length of stay, and costs varied by type of transplant and mycosis. CONCLUSION: The clinical and economic burden of IFIs in transplant recipients may be high.
BACKGROUND:Patients with a solid organ transplant (SOTs) and hematopoietic stem cell or bone marrow transplants (HSC/BMTs) are at risk of contracting invasive fungal infections (IFIs). Data on the economic burden of IFIs in the United States are sparse. METHODS: We conducted a retrospective matched cohort study using the 2004-2005 Healthcare Cost and Utilization Project Nationwide Inpatient Sample. The IFI cohort included patients with ICD-9-CM codes indicating a transplant procedure and an IFI. Matched controls (transplant recipients without an IFI) were chosen based on age (10 year categories), sex, region, hospital type, year, and transplant type. Mortality, length of stay, and costs were reported overall, by transplant type, and by type of mycosis. RESULTS: Nine thousand eight hundred ninety-six patients underwent SOT, and 4661 underwent HSC/BMT. Of these, 80 (0.8%) SOT and 111 (2.4%) HSC/BMT patients had an IFI. Mean age was 41.8 years (SOT) and 37.8 years (HSC/BMT). Aspergillosis was the most common infection. Patients with an IFI had a 5-fold increase in mortality, an additional 19.2 hospital days, and $55,400 in excess costs compared with patients without an IFI. Excess mortality, length of stay, and costs varied by type of transplant and mycosis. CONCLUSION: The clinical and economic burden of IFIs in transplant recipients may be high.
Authors: Caroline N Jones; Laurie Dimisko; Kevin Forrest; Kevin Judice; Mark C Poznansky; James F Markmann; Jatin M Vyas; Daniel Irimia Journal: J Infect Dis Date: 2015-08-12 Impact factor: 5.226
Authors: Jenny M Tam; Jennifer L Reedy; Daniel P Lukason; Sunnie G Kuna; Mridu Acharya; Nida S Khan; Paige E Negoro; Shuying Xu; Rebecca A Ward; Michael B Feldman; Richard A Dutko; Jane B Jeffery; Anna Sokolovska; Carl N Wivagg; Kara G Lassen; François Le Naour; Vasiliki Matzaraki; Ethan C Garner; Ramnik J Xavier; Vinod Kumar; Frank L van de Veerdonk; Mihai G Netea; Cindy K Miranti; Michael K Mansour; Jatin M Vyas Journal: J Immunol Date: 2019-04-22 Impact factor: 5.422
Authors: Raelene E Trudeau; Lyndsey J Bowman; Angela R Wills; Jeffrey S Crippin; William C Chapman; Christopher Anderson Journal: HPB (Oxford) Date: 2012-11-22 Impact factor: 3.647
Authors: M Jurado; J Sainz; C B Lupiañez; M Martínez-Bueno; J M Sánchez-Maldonado; J Badiola; C Cunha; J Springer; M Lackner; J Segura-Catena; L M Canet; L Alcazar-Fuoli; M A López-Nevot; L Fianchi; J M Aguado; L Pagano; E López-Fernández; M Alarcón-Riquelme; L Potenza; S M Gonçalves; M Luppi; L Moratalla; C Solano; A Sampedro; P González-Sierra; M Cuenca-Estrella; K Lagrou; J A Maertens; C Lass-Flörl; H Einsele; L Vazquez; J Loeffler; R Ríos-Tamayo; A Carvalho Journal: Infect Immun Date: 2020-03-23 Impact factor: 3.441