Literature DB >> 20959655

CD200 (OX-2 membrane glycoprotein) expression in b cell-derived neoplasms.

David M Dorfman1, Aliakbar Shahsafaei.   

Abstract

We studied the expression of CD200, an immunoglobulin superfamily membrane glycoprotein, in a wide range of B cell-derived neoplasms by immunohistochemical staining of paraffin-embedded tissue sections. In addition to chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), CD200 is expressed in other B-cell lymphoproliferative disorders, including hairy cell leukemia. In addition, neoplastic cells in classical Hodgkin lymphoma are immunoreactive for CD200. CD200 was previously reported to be expressed in acute myeloid leukemia, and we find that it is also expressed in B-lymphoblastic leukemia/lymphoma. We conclude that CD200 may be a useful immunophenotypic marker in the evaluation of B cell-derived neoplasms. Furthermore, since an anti-CD200 immunotherapeutic agent is in clinical trials, a number of B cell-derived neoplasms in addition to CLL/SLL may be suitable therapeutic targets.

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Year:  2010        PMID： 20959655     DOI： 10.1309/AJCP38XRRUGSQOVC

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  10 in total

1.  Distinction between asymptomatic monoclonal B-cell lymphocytosis with cyclin D1 overexpression and mantle cell lymphoma: from molecular profiling to flow cytometry.

Authors:  Blanca Espinet; Ana Ferrer; Beatriz Bellosillo; Lara Nonell; Antonio Salar; Concepción Fernández-Rodríguez; Eulàlia Puigdecanet; Javier Gimeno; Mar Garcia-Garcia; Maria Carmen Vela; Elisa Luño; Rosa Collado; José Tomás Navarro; Esmeralda de la Banda; Pau Abrisqueta; Leonor Arenillas; Cristina Serrano; Josep Lloreta; Belén Miñana; Andrea Cerutti; Lourdes Florensa; Alberto Orfao; Ferran Sanz; Francesc Solé; David Dominguez-Sola; Sergio Serrano
Journal:  Clin Cancer Res       Date:  2013-12-18       Impact factor: 12.531

2.  Diagnostic usefulness and prognostic impact of CD200 expression in lymphoid malignancies and plasma cell myeloma.

Authors:  Daisy Alapat; Jean Coviello-Malle; Rebecca Owens; Pingping Qu; Bart Barlogie; John D Shaughnessy; Robert B Lorsbach
Journal:  Am J Clin Pathol       Date:  2012-01       Impact factor: 2.493

3.  A comprehensive immunophenotypic marker analysis of hairy cell leukemia in paraffin-embedded bone marrow trephine biopsies--a tissue microarray study.

Authors:  Judit Tóth-Lipták; Klára Piukovics; Zita Borbényi; Judit Demeter; Enikő Bagdi; László Krenács
Journal:  Pathol Oncol Res       Date:  2014-06-06       Impact factor: 3.201

4.  Differential Expression of CD43, CD81, and CD200 in Classic Versus Variant Hairy Cell Leukemia.

Authors:  Dalia A Salem; Drake Scott; Catharine S McCoy; David J Liewehr; David J Venzon; Evgeny Arons; Robert J Kreitman; Maryalice Stetler-Stevenson; Constance M Yuan
Journal:  Cytometry B Clin Cytom       Date:  2019-05-11       Impact factor: 3.058

5.  The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection.

Authors:  Ryan D Estep; Stephanie D Rawlings; Helen Li; Minsha Manoharan; Elizabeth T Blaine; Megan A O'Connor; Ilhem Messaoudi; Michael K Axthelm; Scott W Wong
Journal:  J Virol       Date:  2014-07-02       Impact factor: 5.103

6.  Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia.

Authors:  Joseph A Fraietta; Kyle A Beckwith; Prachi R Patel; Marco Ruella; Zhaohui Zheng; David M Barrett; Simon F Lacey; Jan Joseph Melenhorst; Shannon E McGettigan; Danielle R Cook; Changfeng Zhang; Jun Xu; Priscilla Do; Jessica Hulitt; Sagar B Kudchodkar; Alexandria P Cogdill; Saar Gill; David L Porter; Jennifer A Woyach; Meixiao Long; Amy J Johnson; Kami Maddocks; Natarajan Muthusamy; Bruce L Levine; Carl H June; John C Byrd; Marcela V Maus
Journal:  Blood       Date:  2016-01-26       Impact factor: 22.113

Review 7.  Smoldering mantle cell lymphoma.

Authors:  Haige Ye; Aakash Desai; Dongfeng Zeng; Krystle Nomie; Jorge Romaguera; Makhdum Ahmed; Michael L Wang
Journal:  J Exp Clin Cancer Res       Date:  2017-12-15

8.  Quantitative flow cytometric evaluation of CD200, CD123, CD43 and CD52 as a tool for the differential diagnosis of mature B-cell neoplasms.

Authors:  Elissandra Machado Arlindo; Natália Aydos Marcondes; Flavo Beno Fernandes; Gustavo Adolpho Moreira Faulhaber
Journal:  Rev Bras Hematol Hemoter       Date:  2017-05-29

9.  CD200 Expression in Neuroendocrine Neoplasms.

Authors:  Jason E Love; Kimberly Thompson; Mark R Kilgore; Maria Westerhoff; Claire E Murphy; Antonios Papanicolau-Sengos; Kinsey A McCormick; Veena Shankaran; Natalie Vandeven; Faith Miller; Astrid Blom; Paul T Nghiem; Steven J Kussick
Journal:  Am J Clin Pathol       Date:  2017-09-01       Impact factor: 2.493

Review 10.  CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance.

Authors:  Giovanni D'Arena; Vincenzo De Feo; Giuseppe Pietrantuono; Elisa Seneca; Giovanna Mansueto; Oreste Villani; Francesco La Rocca; Fiorella D'Auria; Teodora Statuto; Luciana Valvano; Francesca Arruga; Silvia Deaglio; Dimitar G Efremov; Alessandro Sgambato; Luca Laurenti
Journal:  Front Oncol       Date:  2020-11-26       Impact factor: 6.244
  10 in total

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