| Literature DB >> 20956830 |
Jennifer Eng-Wong1, Joseph P Costantino, Sandra M Swain.
Abstract
Following local therapy for ductal carcinoma in situ (DCIS), tamoxifen reduces the risk of ipsilateral and contralateral breast cancer by 30%-50%. Studies of tamoxifen in women with resected DCIS have not shown any effect on overall or cancer-specific survival. The adverse event profile of tamoxifen is well characterized, and individual risks and benefits should be assessed to guide decision making. We review the results of the phase III trials of tamoxifen in DCIS as well as the emerging risk reduction therapies.Entities:
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Year: 2010 PMID: 20956830 PMCID: PMC4999067 DOI: 10.1093/jncimonographs/lgq021
Source DB: PubMed Journal: J Natl Cancer Inst Monogr ISSN: 1052-6773