| Literature DB >> 20954722 |
Billy Joel Cabanillas1, Anne-Cécile Le Lamer, Denis Castillo, Jorge Arevalo, Rosario Rojas, Guillaume Odonne, Geneviève Bourdy, Béatrice Moukarzel, Michel Sauvain, Nicolas Fabre.
Abstract
Three new caffeic acid esters (1-3), four new lignans (4-7), and the known compounds (7'S)-parabenzlactone (8), dihydrocubebin (9), and justiflorinol (10) have been isolated from leaves of Piper sanguineispicum. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRCIMS, CD experiments, and chemical methods. Compounds 1-10 were assessed for their antileishmanial potential against axenic amastigote forms of Leishmania amazonensis. Caffeic acid esters 1 and 3 exhibited the best antileishmanial activity (IC(50) 2.0 and 1.8 μM, respectively) with moderate cytotoxicity on murine macrophages.Entities:
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Year: 2010 PMID： 20954722 DOI： 10.1021/np1005357
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050