Literature DB >> 20954157

Measurement of uroporphyrinogen decarboxylase activity.

J D Phillips1, J P Kushner.   

Abstract

Uroporphyrinogen decarboxylase (UROD) catalyzes decarboxylation of the four acetate side chains of urophyrinogen to form coproporphyrinogen. Activity of UROD can be measured using an enzymatically prepared substrate or a chemically prepared one. For the former, bacterial porphobilinogen deaminase is prepared and used to prepare the porphyrinogen substrate for the enzymatic assay. Erythrocyte lysates can be used to measure hemoglobin content as an indicator of UROD activity.

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Year:  2001        PMID： 20954157     DOI： 10.1002/0471140856.tx0804s00

Source DB:  PubMed          Journal:  Curr Protoc Toxicol        ISSN： 1934-9254


  3 in total

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Authors:  Robert B Piel; Mesafint T Shiferaw; Ajay A Vashisht; Jason R Marcero; Jeremy L Praissman; John D Phillips; James A Wohlschlegel; Amy E Medlock
Journal:  Biochemistry       Date:  2016-09-09       Impact factor: 3.162

2.  Sampangine inhibits heme biosynthesis in both yeast and human.

Authors:  Zhiwei Huang; Kaifu Chen; Tao Xu; Jianhuai Zhang; Yongxiang Li; Wei Li; Ameeta K Agarwal; Alice M Clark; John D Phillips; Xuewen Pan
Journal:  Eukaryot Cell       Date:  2011-09-09

3.  A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase.

Authors:  Kenneth W Yip; Zhan Zhang; Noriko Sakemura-Nakatsugawa; Jui-Wen Huang; Nhu Mai Vu; Yi-Kun Chiang; Chih-Lung Lin; Jennifer Y Y Kwan; Shijun Yue; Yulia Jitkova; Terence To; Payam Zahedi; Emil F Pai; Aaron D Schimmer; Jonathan F Lovell; Jonathan L Sessler; Fei-Fei Liu
Journal:  PLoS One       Date:  2014-02-25       Impact factor: 3.240
  3 in total

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