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Literature DB >> 20953176

Efficient CNS gene delivery by intravenous injection.

Jean-Pierre Louboutin¹, Alena A Chekmasova, Elena Marusich, J Roy Chowdhury, David S Strayer.

Abstract

We administered recombinant SV40-derived viral vectors (rSV40s) intravenously to mice with or without prior intraperitoneal injection of mannitol to deliver transgenes to the central nervous system (CNS). We detected transgene-expressing cells (mainly neurons) most prominently in the cortex and spinal cord; prior intraperitoneal mannitol injection increased CNS gene delivery tenfold. Intravenous injection of rSV40s, particularly with mannitol pretreatment, resulted in extensive expression of multiple transgenes throughout the CNS.

Entities: Chemical Species

Mesh：

Year: 2010 PMID： 20953176 DOI： 10.1038/nmeth.1518

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

26 in total

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