Colchicine in the treatment of subcorneal pustular dermatosis.

A male patient with subcorneal pustular dermatosis was initially treated with dapsone with excellent response. Since he developed hypersensitivity to dapsone, corticosteroid was given instead of dapsone. But steroid also was withdrawn since he developed hypertension and diabetes. There was relapse of skin lesions which were treated with oral colchicine, which has profound inhibitory effects on neutrophils. There was excellent therapeutic response to colchicine and the drug well-tolerated.