OBJECTIVE: to describe the longterm clinical and radiological outcomes in rheumatoid arthritis (RA) in a cohort in northwestern Greece; and to investigate predictive factors of radiological damage at the 10-year followup in patients with RA. METHODS: we studied the disease course and outcome of 144 patients with RA and radiographs of the hands and wrists available at baseline and at 10 years. Baseline measurements and time-averaged measures of swollen joint count (SJC) and inflammatory markers [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)] were tested in univariate analysis, and then those presenting a statistically significant association with either Larsen score at 10 years or annual progression rate were included in 2 logistic regression models in order to determine relevant independent prognostic factors. RESULTS: a significant clinical improvement was noted, associated with a decrease of inflammatory markers along the timepoints. Larsen score and the number of erosive joints were increased. In the univariate analysis, both final Larsen score at 10 years and accelerated annual radiological progression rate were significantly associated with baseline radiographic measurements (Larsen score and number of erosive joints), the presence of autoantibodies [anticyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor of IgA and IgM isotype], disease duration, and time-averaged measures of ESR, CRP, and SJC. In the logistic regression analysis, the baseline Larsen score, anti-CCP antibodies, and time-averaged CRP presented significant and independent associations with Larsen score at 10 years. An accelerated annual radiological progression rate was also predicted by baseline Larsen score and time-averaged measures of SJC and CRP. CONCLUSION: despite clinical improvement, the radiologic progression of RA continues over time, because of the underlying inflammatory process. Baseline radiographic damage, anti-CCP antibodies, and time-averaged CRP constitute the main predictive factors of poor radiologic outcome in the long term.
OBJECTIVE: to describe the longterm clinical and radiological outcomes in rheumatoid arthritis (RA) in a cohort in northwestern Greece; and to investigate predictive factors of radiological damage at the 10-year followup in patients with RA. METHODS: we studied the disease course and outcome of 144 patients with RA and radiographs of the hands and wrists available at baseline and at 10 years. Baseline measurements and time-averaged measures of swollen joint count (SJC) and inflammatory markers [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)] were tested in univariate analysis, and then those presenting a statistically significant association with either Larsen score at 10 years or annual progression rate were included in 2 logistic regression models in order to determine relevant independent prognostic factors. RESULTS: a significant clinical improvement was noted, associated with a decrease of inflammatory markers along the timepoints. Larsen score and the number of erosive joints were increased. In the univariate analysis, both final Larsen score at 10 years and accelerated annual radiological progression rate were significantly associated with baseline radiographic measurements (Larsen score and number of erosive joints), the presence of autoantibodies [anticyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor of IgA and IgM isotype], disease duration, and time-averaged measures of ESR, CRP, and SJC. In the logistic regression analysis, the baseline Larsen score, anti-CCP antibodies, and time-averaged CRP presented significant and independent associations with Larsen score at 10 years. An accelerated annual radiological progression rate was also predicted by baseline Larsen score and time-averaged measures of SJC and CRP. CONCLUSION: despite clinical improvement, the radiologic progression of RA continues over time, because of the underlying inflammatory process. Baseline radiographic damage, anti-CCP antibodies, and time-averaged CRP constitute the main predictive factors of poor radiologic outcome in the long term.
Authors: Laura M Raffield; Apoorva K Iyengar; Biqi Wang; Sheila M Gaynor; Cassandra N Spracklen; Xue Zhong; Madeline H Kowalski; Shabnam Salimi; Linda M Polfus; Emelia J Benjamin; Joshua C Bis; Russell Bowler; Brian E Cade; Won Jung Choi; Alejandro P Comellas; Adolfo Correa; Pedro Cruz; Harsha Doddapaneni; Peter Durda; Stephanie M Gogarten; Deepti Jain; Ryan W Kim; Brian G Kral; Leslie A Lange; Martin G Larson; Cecelia Laurie; Jiwon Lee; Seonwook Lee; Joshua P Lewis; Ginger A Metcalf; Braxton D Mitchell; Zeineen Momin; Donna M Muzny; Nathan Pankratz; Cheol Joo Park; Stephen S Rich; Jerome I Rotter; Kathleen Ryan; Daekwan Seo; Russell P Tracy; Karine A Viaud-Martinez; Lisa R Yanek; Lue Ping Zhao; Xihong Lin; Bingshan Li; Yun Li; Josée Dupuis; Alexander P Reiner; Karen L Mohlke; Paul L Auer Journal: Am J Hum Genet Date: 2019-12-26 Impact factor: 11.025
Authors: John M Davis; Keith L Knutson; John A Skinner; Michael A Strausbauch; Cynthia S Crowson; Terry M Therneau; Peter J Wettstein; Eric L Matteson; Sherine E Gabriel Journal: Arthritis Res Ther Date: 2012-01-31 Impact factor: 5.156
Authors: Nirmal K Banda; V Michael Holers; Dhruv Desai; Robert I Scheinman; Rasmus Pihl; Hideharu Sekine; Teizo Fujita; Vibha Sharma; Annette G Hansen; Peter Garred; Steffen Thiel; Anna Borodovsky Journal: Immunohorizons Date: 2018-09
Authors: V Michael Holers; Anna Borodovsky; Robert I Scheinman; Nhu Ho; Joseline Ramos Ramirez; József Dobó; Péter Gál; Jared Lindenberger; Annette G Hansen; Dhruv Desai; Rasmus Pihl; Steffen Thiel; Nirmal K Banda Journal: Front Immunol Date: 2020-02-21 Impact factor: 7.561