OBJECTIVE: 25-hydroxy-vitamin D (25-OH-D) insufficiency/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence and associations of 25-OH-D insufficiency/deficiency in a cohort of US veterans with RA. METHODS: vitamin D status (25-OH-D) was assessed in patients with RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency was defined as concentrations < 30 ng/ml and deficiency as < 20 ng/ml. Associations of 25-OH-D insufficiency/deficiency with patient characteristics obtained at enrollment were examined using multivariate logistic regression, adjusting for age, sex, season of enrollment, and race. RESULTS: patients (850 men, 76% Caucasian) had a mean (SD) age of 64 (SD 11.3) years. The prevalences of 25-OH-D insufficiency and deficiency were 84% and 43%, respectively. After multivariate adjustment, both insufficiency and deficiency were more common with anti-cyclic citrullinated peptide antibody positivity and non-Caucasian race, and in the absence of vitamin D supplementation. 25-OH-D deficiency, but not insufficiency, was independently associated with higher tender joint counts and highly sensitive C-reactive protein levels. CONCLUSION: in a predominantly elderly, male RA population, 25-OH-D insufficiency was highly prevalent. With the increasing adverse health outcomes associated with hypovitaminosis D, screening and supplementation, particularly among minority, seropositive patients with RA, should be performed routinely.
OBJECTIVE:25-hydroxy-vitamin D (25-OH-D) insufficiency/deficiency is increasingly prevalent and has been associated with many chronic diseases, including rheumatoid arthritis (RA). Our purpose was to define the prevalence and associations of 25-OH-Dinsufficiency/deficiency in a cohort of US veterans with RA. METHODS:vitamin D status (25-OH-D) was assessed in patients with RA using radioimmunoassay on banked plasma collected at enrollment. Insufficiency was defined as concentrations < 30 ng/ml and deficiency as < 20 ng/ml. Associations of 25-OH-Dinsufficiency/deficiency with patient characteristics obtained at enrollment were examined using multivariate logistic regression, adjusting for age, sex, season of enrollment, and race. RESULTS:patients (850 men, 76% Caucasian) had a mean (SD) age of 64 (SD 11.3) years. The prevalences of 25-OH-Dinsufficiency and deficiency were 84% and 43%, respectively. After multivariate adjustment, both insufficiency and deficiency were more common with anti-cyclic citrullinated peptide antibody positivity and non-Caucasian race, and in the absence of vitamin D supplementation. 25-OH-D deficiency, but not insufficiency, was independently associated with higher tender joint counts and highly sensitive C-reactive protein levels. CONCLUSION: in a predominantly elderly, male RA population, 25-OH-Dinsufficiency was highly prevalent. With the increasing adverse health outcomes associated with hypovitaminosis D, screening and supplementation, particularly among minority, seropositive patients with RA, should be performed routinely.
Authors: Jean Lucas G da Silva; Daniela F Passos; Viviane M Bernardes; Fernanda L Cabral; Paulo G Schimites; Alessandra G Manzoni; Edilene Gadelha de Oliveira; Cristiane de Bona da Silva; Ruy Carlos Ruver Beck; Matheus H Jantsch; Roberto M Maciel; Daniela B R Leal Journal: Inflammation Date: 2019-10 Impact factor: 4.092
Authors: Pascale Schwab; Harlan Sayles; Debra Bergman; Grant W Cannon; Kaleb Michaud; Ted R Mikuls; Jennifer Barton Journal: Arthritis Care Res (Hoboken) Date: 2017-05-09 Impact factor: 4.794
Authors: Hans-Jacob Haga; Anne Schmedes; Yusuf Naderi; Alicia Martin Moreno; Elisabeth Peen Journal: Clin Rheumatol Date: 2013-01-15 Impact factor: 2.980