OBJECTIVE: This study aimed to investigate the roles of the epidermal growth factor receptor (EGFR) family members and their ligands in oral lichen planus (OLP). STUDY DESIGN: The expressions of 4 EGFR-like receptors and 6 EGF-like ligands were measured in OLP tissues from 10 patients and compared with the levels in normal oral mucosa (NOM) from 10 healthy donors. RESULTS: Of the receptors, only EGFR mRNA and protein were more highly expressed in OLP compared with NOM tissues. Regarding the ligands, the mRNAs of amphiregulin (AREG), epiregulin (EREG), and heparin-binding EGF-like growth factor (HB-EGF) were more highly expressed in OLP compared with NOM tissues. These ligands were strongly expressed by infiltrating lamina propria lymphocytes as well as epithelial keratinocytes in OLP lesions, as shown by immunohistochemistry. CONCLUSIONS: The enhanced EGFR expression on the keratinocytes in OLP lesions and the up-regulation of EGF-like ligands in keratinocytes and infiltrating mononuclear cells could contribute to the carcinogenesis and pathogenesis of OLP.
OBJECTIVE: This study aimed to investigate the roles of the epidermal growth factor receptor (EGFR) family members and their ligands in oral lichen planus (OLP). STUDY DESIGN: The expressions of 4 EGFR-like receptors and 6 EGF-like ligands were measured in OLP tissues from 10 patients and compared with the levels in normal oral mucosa (NOM) from 10 healthy donors. RESULTS: Of the receptors, only EGFR mRNA and protein were more highly expressed in OLP compared with NOM tissues. Regarding the ligands, the mRNAs of amphiregulin (AREG), epiregulin (EREG), and heparin-binding EGF-like growth factor (HB-EGF) were more highly expressed in OLP compared with NOM tissues. These ligands were strongly expressed by infiltrating lamina propria lymphocytes as well as epithelial keratinocytes in OLP lesions, as shown by immunohistochemistry. CONCLUSIONS: The enhanced EGFR expression on the keratinocytes in OLP lesions and the up-regulation of EGF-like ligands in keratinocytes and infiltrating mononuclear cells could contribute to the carcinogenesis and pathogenesis of OLP.
Authors: Meredith C Hitch; Jennifer A Leinicke; Derek Wakeman; Jun Guo; Chris R Erwin; Kathryn J Rowland; Ellen C Merrick; Robert O Heuckeroth; Brad W Warner Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-03-15 Impact factor: 4.052
Authors: Holbrook E Kohrt; Lu Tian; Li Li; Ash A Alizadeh; Sue Hsieh; Robert J Tibshirani; Samuel Strober; Minnie Sarwal; Robert Lowsky Journal: Clin Immunol Date: 2013-05-01 Impact factor: 3.969
Authors: Keigo Suzukawa; Julia Tomlin; Kwang Pak; Eduardo Chavez; Arwa Kurabi; Andrew Baird; Stephen I Wasserman; Allen F Ryan Journal: PLoS One Date: 2014-07-17 Impact factor: 3.240