| Literature DB >> 20952196 |
Junwon Lee1, Jong Yup Kim, Jungsub Choi, Sung-Han Lee, Jeongmin Kim, Jinhwa Lee.
Abstract
Novel C-aryl glucoside SGLT2 inhibitors containing pyrimidine motif were designed and synthesized for biological evaluation. Among the compounds assayed, pyrimidine containing methylthio moiety 11 g demonstrated the best in vitro inhibitory activity against SGLT2 in this series to date (IC(50)=10.7 nM).Entities:
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Year: 2010 PMID： 20952196 DOI： 10.1016/j.bmcl.2010.09.103
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823