Literature DB >> 20952040

Sebestenoids A-D, BACE1 inhibitors from Cordia sebestena.

Jingqiu Dai1, Analia Sorribas, Wesley Y Yoshida, Philip G Williams.   

Abstract

Bioassay-guided fractionation of an extract prepared from the fruits of Cordia sebestena led to the isolation of sebestenoids A-D (1-4). Their structures were elucidated on the basis of extensive NMR experiments and mass spectroscopic measurements. Compounds 1-4 exhibited moderate inhibition of the aspartic protease BACE1.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20952040      PMCID: PMC2984665          DOI: 10.1016/j.phytochem.2010.09.008

Source DB:  PubMed          Journal:  Phytochemistry        ISSN: 0031-9422            Impact factor:   4.072


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