Literature DB >> 20951925

Therapeutic potential of peroxisome proliferator-activated receptors in chronic inflammation and colorectal cancer.

Dingzhi Wang1, Raymond N DuBois.   

Abstract

Peroxisome proliferatoreactivated receptors (PPARs) are members of the nuclear hormone receptor superfamily and have been implicated in a variety of physiologic and pathologic processes, such as nutrient metabolism, energy homeostasis, inflammation, and cancer. This article highlights breakthroughs in our understanding of the potential roles of PPARs in inflammatory bowel disease and colorectal cancer. PPARs might hold the key to some of the questions that are pertinent to the pathophysiology of inflammatory diseases and colorectal cancer and could possibly serve as drug targets for new antiinflammatory therapeutic and anticancer agents.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20951925      PMCID： PMC2957674          DOI： 10.1016/j.gtc.2010.08.014

Source DB:  PubMed          Journal:  Gastroenterol Clin North Am        ISSN： 0889-8553            Impact factor:   3.806


  83 in total

1.  Loss-of-function mutations in PPAR gamma associated with human colon cancer.

Authors:  P Sarraf; E Mueller; W M Smith; H M Wright; J B Kum; L A Aaltonen; A de la Chapelle; B M Spiegelman; C Eng
Journal:  Mol Cell       Date:  1999-06       Impact factor: 17.970

2.  A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response.

Authors:  C G Su; X Wen; S T Bailey; W Jiang; S M Rangwala; S A Keilbaugh; A Flanigan; S Murthy; M A Lazar; G D Wu
Journal:  J Clin Invest       Date:  1999-08       Impact factor: 14.808

Review 3.  Colorectal cancer and nonsteroidal anti-inflammatory drugs.

Authors:  W E Smalley; R N DuBois
Journal:  Adv Pharmacol       Date:  1997

4.  Activators of the nuclear receptor PPARgamma enhance colon polyp formation.

Authors:  E Saez; P Tontonoz; M C Nelson; J G Alvarez; U T Ming; S M Baird; V A Thomazy; R M Evans
Journal:  Nat Med       Date:  1998-09       Impact factor: 53.440

5.  Differentiation and reversal of malignant changes in colon cancer through PPARgamma.

Authors:  P Sarraf; E Mueller; D Jones; F J King; D J DeAngelo; J B Partridge; S A Holden; L B Chen; S Singer; C Fletcher; B M Spiegelman
Journal:  Nat Med       Date:  1998-09       Impact factor: 53.440

6.  Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice.

Authors:  A M Lefebvre; I Chen; P Desreumaux; J Najib; J C Fruchart; K Geboes; M Briggs; R Heyman; J Auwerx
Journal:  Nat Med       Date:  1998-09       Impact factor: 53.440

7.  The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers.

Authors:  R N DuBois; R Gupta; J Brockman; B S Reddy; S L Krakow; M A Lazar
Journal:  Carcinogenesis       Date:  1998-01       Impact factor: 4.944

Review 8.  Dietary fat and carcinogenesis.

Authors:  R A Woutersen; M J Appel; A van Garderen-Hoetmer; M V Wijnands
Journal:  Mutat Res       Date:  1999-07-15       Impact factor: 2.433

Review 9.  Cancer risk in patients with inflammatory bowel disease.

Authors:  J D Lewis; J J Deren; G R Lichtenstein
Journal:  Gastroenterol Clin North Am       Date:  1999-06       Impact factor: 3.806

10.  Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

Authors:  J M Peters; R C Cattley; F J Gonzalez
Journal:  Carcinogenesis       Date:  1997-11       Impact factor: 4.944
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  10 in total

1.  PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis.

Authors:  Dingzhi Wang; Lingchen Fu; Jie Wei; Ying Xiong; Raymond N DuBois
Journal:  Cancer Res       Date:  2019-06-25       Impact factor: 12.701

2.  Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth.

Authors:  Dingzhi Wang; Lingchen Fu; Wei Ning; Lixia Guo; Xiaofei Sun; Sudhansu K Dey; Rupesh Chaturvedi; Keith T Wilson; Raymond N DuBois
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-24       Impact factor: 11.205

3.  Unveiling differentially expressed genes upon regulation of transcription factors in sepsis.

Authors:  Junli Zhang; Yuelei Cheng; Minmin Duan; Nannan Qi; Jian Liu
Journal:  3 Biotech       Date:  2017-04-25       Impact factor: 2.406

4.  Association of COX2 gene hypomethylation with intestinal type gastric cancer in samples of patients from northern Brazil.

Authors:  Cynthia Farias Vieira de Melo; Carolina Oliveira Gigek; Juarez Nóbrega da Silva; Marilia de Arruda Cardoso Smith; Rubistenia Miranda de Araújo; Rommel Rodríguez Burbano; Eleonidas Moura Lima
Journal:  Tumour Biol       Date:  2013-09-07

Review 5.  Towards novel radiosensitizing agents: the role of cytosolic PLA2α in combined modality cancer therapy.

Authors:  Jeffrey M Craft; Dennis Hallahan
Journal:  Future Med Chem       Date:  2011-05       Impact factor: 3.808

6.  Microbial dysbiosis and colon carcinogenesis: could colon cancer be considered a bacteria-related disease?

Authors:  Iradj Sobhani; Aurelien Amiot; Yann Le Baleur; Michael Levy; Marie-Luce Auriault; Jeanne Tran Van Nhieu; Jean Charles Delchier
Journal:  Therap Adv Gastroenterol       Date:  2013-05       Impact factor: 4.409

7.  Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes.

Authors:  Sarah-Salwa Nebbaki; Fatima Ezzahra El Mansouri; Hassan Afif; Mohit Kapoor; Mohamed Benderdour; Nicolas Duval; Jean-Pierre Pelletier; Johanne Martel-Pelletier; Hassan Fahmi
Journal:  Arthritis Res Ther       Date:  2012-03-28       Impact factor: 5.156

8.  Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD.

Authors:  Øystein Brenna; Marianne W Furnes; Ignat Drozdov; Atle van Beelen Granlund; Arnar Flatberg; Arne K Sandvik; Rosalie T M Zwiggelaar; Ronald Mårvik; Ivar S Nordrum; Mark Kidd; Björn I Gustafsson
Journal:  PLoS One       Date:  2013-01-31       Impact factor: 3.240

9.  Repositioning drugs for inflammatory disease - fishing for new anti-inflammatory agents.

Authors:  Christopher J Hall; Sophie M Wicker; An-Tzu Chien; Alisha Tromp; Lisa M Lawrence; Xueying Sun; Geoffrey W Krissansen; Kathryn E Crosier; Philip S Crosier
Journal:  Dis Model Mech       Date:  2014-07-18       Impact factor: 5.758

10.  Profiling the lncRNA-miRNA-mRNA ceRNA network to reveal potential crosstalk between inflammatory bowel disease and colorectal cancer.

Authors:  Fangfang Sun; Weiwei Liang; Kejun Tang; Mengying Hong; Jing Qian
Journal:  PeerJ       Date:  2019-08-26       Impact factor: 2.984
  10 in total

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