PURPOSE: To investigate the behavior of tumor subvolumes of high [18F]-fluorodeoxyglucose (FDG) uptake as seen on clinical four-dimensional (4D) FDG-positron emission tomography (PET) scans. METHODS AND MATERIALS: Four-dimensional FDG-PET/computed tomography scans from 13 patients taken before radiotherapy were available. The analysis was focused on regions of high uptake that are potential dose-painting targets. A total of 17 lesions (primary tumors and lymph nodes) were analyzed. On each one of the five phases of the 4D scan a classification algorithm was applied to obtain the region of highest uptake and segment the tumor volume. We looked at the behavior of both the high-uptake subvolume, called "Boost," and the segmented tumor volume, called "Target." We measured several quantities that characterize the Target and Boost volumes and quantified correlations between them. RESULTS: The behavior of the Target could not always predict the behavior of the Boost. The shape deformation of the Boost regions was on average 133% higher than that of the Target. The gross to internal target volume expansion was on average 27.4% for the Target and 64% for the Boost, a statistically significant difference (p < 0.05). Finally, the inhale-to-exhale phase (20%) had the highest shape deformation for the Boost regions. CONCLUSIONS: A complex relationship between the measured quantities for the Boost and Target volumes is revealed. The results suggest that in cases in which advanced therapy techniques such as dose painting are being used, a close examination of the 4D PET scan should be performed.
PURPOSE: To investigate the behavior of tumor subvolumes of high [18F]-fluorodeoxyglucose (FDG) uptake as seen on clinical four-dimensional (4D) FDG-positron emission tomography (PET) scans. METHODS AND MATERIALS: Four-dimensional FDG-PET/computed tomography scans from 13 patients taken before radiotherapy were available. The analysis was focused on regions of high uptake that are potential dose-painting targets. A total of 17 lesions (primary tumors and lymph nodes) were analyzed. On each one of the five phases of the 4D scan a classification algorithm was applied to obtain the region of highest uptake and segment the tumor volume. We looked at the behavior of both the high-uptake subvolume, called "Boost," and the segmented tumor volume, called "Target." We measured several quantities that characterize the Target and Boost volumes and quantified correlations between them. RESULTS: The behavior of the Target could not always predict the behavior of the Boost. The shape deformation of the Boost regions was on average 133% higher than that of the Target. The gross to internal target volume expansion was on average 27.4% for the Target and 64% for the Boost, a statistically significant difference (p < 0.05). Finally, the inhale-to-exhale phase (20%) had the highest shape deformation for the Boost regions. CONCLUSIONS: A complex relationship between the measured quantities for the Boost and Target volumes is revealed. The results suggest that in cases in which advanced therapy techniques such as dose painting are being used, a close examination of the 4D PET scan should be performed.
Authors: Stephen R Bowen; Larry A Pierce; Adam M Alessio; Chi Liu; Scott D Wollenweber; Charles W Stearns; Paul E Kinahan Journal: J Med Imaging (Bellingham) Date: 2014-09-24
Authors: Mathieu Hatt; John A Lee; Charles R Schmidtlein; Issam El Naqa; Curtis Caldwell; Elisabetta De Bernardi; Wei Lu; Shiva Das; Xavier Geets; Vincent Gregoire; Robert Jeraj; Michael P MacManus; Osama R Mawlawi; Ursula Nestle; Andrei B Pugachev; Heiko Schöder; Tony Shepherd; Emiliano Spezi; Dimitris Visvikis; Habib Zaidi; Assen S Kirov Journal: Med Phys Date: 2017-05-18 Impact factor: 4.071
Authors: Shouyi Wang; Stephen R Bowen; W Art Chaovalitwongse; George A Sandison; Thomas J Grabowski; Paul E Kinahan Journal: Phys Med Biol Date: 2014-02-07 Impact factor: 3.609
Authors: Shyam S Jani; Clifford G Robinson; Magnus Dahlbom; Benjamin M White; David H Thomas; Sergio Gaudio; Daniel A Low; James M Lamb Journal: Int J Radiat Oncol Biol Phys Date: 2013-11-01 Impact factor: 7.038
Authors: S R Bowen; M J Nyflot; C Herrmann; C M Groh; J Meyer; S D Wollenweber; C W Stearns; P E Kinahan; G A Sandison Journal: Phys Med Biol Date: 2015-04-17 Impact factor: 3.609
Authors: Eunsin Lee; Jing Zeng; Robert S Miyaoka; Jatinder Saini; Paul E Kinahan; George A Sandison; Tony Wong; Hubert J Vesselle; Ramesh Rengan; Stephen R Bowen Journal: Med Phys Date: 2017-06-01 Impact factor: 4.071
Authors: Hannah Mary Thomas; Paul E Kinahan; James Jebaseelan E Samuel; Stephen R Bowen Journal: J Med Imaging Radiat Oncol Date: 2017-11-28 Impact factor: 1.735
Authors: Stephen R Bowen; Matthew J Nyflot; Michael Gensheimer; Kristi R G Hendrickson; Paul E Kinahan; George A Sandison; Shilpen A Patel Journal: Clin Transl Med Date: 2012-08-31