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Literature DB >> 20950703

Regulation of sodium channel activity by phosphorylation.

Abstract

Voltage-gated sodium channels carry the major inward current responsible for action potential depolarization in excitable cells as well as providing additional inward current that modulates overall excitability. Both their expression and function is under tight control of protein phosphorylation by specific kinases and phosphatases and this control is particular to each type of sodium channel. This article examines the impact and mechanism of phosphorylation for isoforms where it has been studied in detail in an attempt to delineate common features as well as differences.

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Year: 2010 PMID： 20950703 PMCID： PMC3423337 DOI： 10.1016/j.semcdb.2010.10.002

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

80 in total

1. A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta.

Authors: C F Ratcliffe; Y Qu; K A McCormick; V C Tibbs; J E Dixon; T Scheuer; W A Catterall
Journal: Nat Neurosci Date: 2000-05 Impact factor: 24.884

Review 2. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.

Authors: W A Catterall
Journal: Neuron Date: 2000-04 Impact factor: 17.173

3. Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes.

Authors: J Zhou; J Yi; N Hu; A L George; K T Murray
Journal: Circ Res Date: 2000-07-07 Impact factor: 17.367

4. Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific sites in the sodium channel alpha subunit.

Authors: A R Cantrell; R D Smith; A L Goldin; T Scheuer; W A Catterall
Journal: J Neurosci Date: 1997-10-01 Impact factor: 6.167

5. Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.

Authors: N W Plummer; M W McBurney; M H Meisler
Journal: J Biol Chem Date: 1997-09-19 Impact factor: 5.157

6. Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A.

Authors: R D Smith; A L Goldin
Journal: J Neurosci Date: 1997-08-15 Impact factor: 6.167

7. Functional analysis of the rat I sodium channel in xenopus oocytes.

Authors: R D Smith; A L Goldin
Journal: J Neurosci Date: 1998-02-01 Impact factor: 6.167

8. Skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase.

Authors: J P Mounsey; D J Mistry; C W Ai; S Reddy; J R Moorman
Journal: Hum Mol Genet Date: 2000-09-22 Impact factor: 6.150

9. Dopaminergic modulation of voltage-gated Na+ current in rat hippocampal neurons requires anchoring of cAMP-dependent protein kinase.

Authors: A R Cantrell; V C Tibbs; R E Westenbroek; T Scheuer; W A Catterall
Journal: J Neurosci Date: 1999-09-01 Impact factor: 6.167

10. Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the src signaling pathway.

Authors: M D Hilborn; R R Vaillancourt; S G Rane
Journal: J Neurosci Date: 1998-01-15 Impact factor: 6.167

45 in total

1. Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations.

Authors: Balazs Horvath; Tamas Banyasz; Zhong Jian; Bence Hegyi; Kornel Kistamas; Peter P Nanasi; Leighton T Izu; Ye Chen-Izu
Journal: J Mol Cell Cardiol Date: 2013-09-06 Impact factor: 5.000

2. Dissipation of transmembrane potassium gradient is the main cause of cerebral ischemia-induced depolarization in astrocytes and neurons.

Authors: Yixing Du; Wei Wang; Anthony D Lutton; Conrad M Kiyoshi; Baofeng Ma; Anne T Taylor; John W Olesik; Dana M McTigue; Candice C Askwith; Min Zhou
Journal: Exp Neurol Date: 2018-02-03 Impact factor: 5.330

10. Pituitary adenylate cyclase-activating polypeptide-induced PAC1 receptor internalization and recruitment of MEK/ERK signaling enhance excitability of dentate gyrus granule cells.

Authors: Gregory C Johnson; Rodney L Parsons; Victor May; Sayamwong E Hammack
Journal: Am J Physiol Cell Physiol Date: 2020-03-18 Impact factor: 4.249

Regulation of sodium channel activity by phosphorylation.

1. A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta.

Review 2. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.

3. Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes.

4. Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific sites in the sodium channel alpha subunit.

5. Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.

6. Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A.

7. Functional analysis of the rat I sodium channel in xenopus oocytes.

8. Skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase.

9. Dopaminergic modulation of voltage-gated Na+ current in rat hippocampal neurons requires anchoring of cAMP-dependent protein kinase.

10. Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the src signaling pathway.

1. Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations.

2. Dissipation of transmembrane potassium gradient is the main cause of cerebral ischemia-induced depolarization in astrocytes and neurons.

3. Delta-opioid receptor-mediated modulation of excitability of individual hippocampal neurons: mechanisms involved.

Review 4. Modulation of sodium channels as pharmacological tool for pain therapy-highlights and gaps.

5. Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia.

6. CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice.

Review 7. Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function.

8. Seizure Suppression by High Temperature via cAMP Modulation in Drosophila.

9. CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability.

10. Pituitary adenylate cyclase-activating polypeptide-induced PAC1 receptor internalization and recruitment of MEK/ERK signaling enhance excitability of dentate gyrus granule cells.