Literature DB >> 20950638

Phospholipase A2 inhibitors (βPLIs) are encoded in the venom glands of Lachesis muta (Crotalinae, Viperidae) snakes.

Rebeca Mascarenhas Lima1, Maria Inácia Estevão-Costa, Inácio L M Junqueira-de-Azevedo, Paulo Lee Ho, Marcelo Ribeiro Vasconcelos Diniz, Consuelo Latorre Fortes-Dias.   

Abstract

Phospholipase A(2) inhibitors (PLIs) are glycoproteins secreted by snake liver into the circulating blood aiming the self-protection against toxic venom phospholipases A(2). In the present study, we describe the first complete nucleotide sequence of a βPLI from venom glands of a New World snake, Lachesis muta. The deduced primary structure was compared to other known βPLIs and recent literature findings of other possible roles of PLIs in snakes are discussed. Copyright Â
© 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20950638     DOI: 10.1016/j.toxicon.2010.10.005

Source DB:  PubMed          Journal:  Toxicon        ISSN: 0041-0101            Impact factor:   3.033


  3 in total

Review 1.  Endogenous phospholipase A2 inhibitors in snakes: a brief overview.

Authors:  Patrícia Cota Campos; Lutiana Amaral de Melo; Gabriel Latorre Fortes Dias; Consuelo Latorre Fortes-Dias
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2016-12-21

2.  Preparation of monoclonal antibodies against gamma-type phospholipase A2 inhibitors and immunodetection of these proteins in snake blood.

Authors:  Jingjing Li; Ying Xiong; Shimin Sun; Lehan Yu; Chunhong Huang
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2017-08-03

3.  Identification, description and structural analysis of beta phospholipase A2 inhibitors (sbβPLIs) from Latin American pit vipers indicate a binding site region for basic snake venom phospholipases A2.

Authors:  Consuelo Latorre Fortes-Dias; Carlos Alexandre H Fernandes; Paula Ladeira Ortolani; Patrícia Cota Campos; L A Melo; Liza Figueiredo Felicori; Marcos Roberto M Fontes
Journal:  Toxicon X       Date:  2019-02-26
  3 in total

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