Mohammad Sarhan1, Hector A DePaz, Soji F D Oluwole. 1. Department of Surgery, Harlem Hospital Center, Columbia University Medical Center, New York, New York 10037, USA. ms3711@columbia.edu
Abstract
BACKGROUND: AIDS and breast cancer have become two important public health issues for women. Of interest is the prolonged survival of patients diagnosed with HIV infection as a result of the use of highly active antiretroviral therapy (HAART). With improved survival, we are likely to see more HIV-infected patients with breast cancer. METHODS: This study, which is a review of our experience at Harlem Hospital Center, New York, between 2000 and 2008, compared HIV-positive with HIV-negative breast cancer patients, with attention to tumor size, stage, grade, molecular markers and lymphovascular invasion, treatment, and patient survival. RESULTS: Only 63 of 370 patients with breast carcinoma were tested for HIV, and 6 of the 63 women tested positive for HIV. We, therefore, compared the clinical features and tumor characteristics seen in the 6 HIV-infected women with those of the 57 HIV-seronegative breast cancer patients. We found no differences in presentation, median age, and tumor morphology in the two groups of patients. When the patients in our previous report on 5 HIV-positive breast cancer patients were added to the present group, the overall 5-year survival rate among the 11 HIV-infected patients was 75%. Of note is the finding that HIV infection in premenopausal women was not associated with aggressive breast cancer subtypes with poor survival outcome. CONCLUSIONS: These results demonstrate that histological subgroups and 5-year survival appear similar among HIV-positive breast cancer patients.
BACKGROUND:AIDS and breast cancer have become two important public health issues for women. Of interest is the prolonged survival of patients diagnosed with HIV infection as a result of the use of highly active antiretroviral therapy (HAART). With improved survival, we are likely to see more HIV-infectedpatients with breast cancer. METHODS: This study, which is a review of our experience at Harlem Hospital Center, New York, between 2000 and 2008, compared HIV-positive with HIV-negative breast cancerpatients, with attention to tumor size, stage, grade, molecular markers and lymphovascular invasion, treatment, and patient survival. RESULTS: Only 63 of 370 patients with breast carcinoma were tested for HIV, and 6 of the 63 women tested positive for HIV. We, therefore, compared the clinical features and tumor characteristics seen in the 6 HIV-infectedwomen with those of the 57 HIV-seronegative breast cancerpatients. We found no differences in presentation, median age, and tumor morphology in the two groups of patients. When the patients in our previous report on 5 HIV-positive breast cancerpatients were added to the present group, the overall 5-year survival rate among the 11 HIV-infectedpatients was 75%. Of note is the finding that HIV infection in premenopausal women was not associated with aggressive breast cancer subtypes with poor survival outcome. CONCLUSIONS: These results demonstrate that histological subgroups and 5-year survival appear similar among HIV-positive breast cancerpatients.
Authors: Victoria M Youngblood; Ruth Nyirenda; Richard Nyasosela; Takondwa Zuze; Yi Yang; Evaristar Kudowa; Agnes Moses; Jennifer Kincaid; Chifundo Kajombo; Coxcilly Kampani; Fred Chimzimu; Maurice Mulenga; Chrissie Chilima; Grace K Ellis; Ryan Seguin; Maganizo Chagomerana; Rebecca Maine; Sheryl Jordan; Anthony Charles; Clara Lee; Satish Gopal; Tamiwe Tomoka Journal: Cancer Causes Control Date: 2020-03-02 Impact factor: 2.506
Authors: Adaah A Sayyed; Stephanie Shin; Areeg A Abu El Hawa; Olutayo Sogunro; Gabriel A Del Corral; Marc E Boisvert; David H Song Journal: Plast Reconstr Surg Glob Open Date: 2022-09-28