BACKGROUND: To date, more than 60 gene expression profiling (GEP) studies have been published in the field of head and neck squamous cell carcinoma (HNSCC) with variable objectives, methods, and results. METHODS: The purpose of this study was to present a state-of-the-art review of GEP in HNSCC focusing on the current advances and perspectives for clinical applications. RESULTS: Gene expression signatures have been developed to identify screening and diagnostic molecular markers, to improve tumor staging (cervical lymph node and distant metastasis prediction), to differentiate lung metastasis of HNSCC from primary lung squamous cell carcinoma, to predict tumor response to chemoradiotherapy, and to provide outcome predictors. CONCLUSION: Some transcriptional signatures that could improve HNSCC management have been identified, but further analyses are required to properly validate and to precisely evaluate their clinical relevance. After an exploratory phase, the completion of large scale projects with stringent methodology is now necessary to transfer GEP from bench to bedside.
BACKGROUND: To date, more than 60 gene expression profiling (GEP) studies have been published in the field of head and neck squamous cell carcinoma (HNSCC) with variable objectives, methods, and results. METHODS: The purpose of this study was to present a state-of-the-art review of GEP in HNSCC focusing on the current advances and perspectives for clinical applications. RESULTS: Gene expression signatures have been developed to identify screening and diagnostic molecular markers, to improve tumor staging (cervical lymph node and distant metastasis prediction), to differentiate lung metastasis of HNSCC from primary lung squamous cell carcinoma, to predict tumor response to chemoradiotherapy, and to provide outcome predictors. CONCLUSION: Some transcriptional signatures that could improve HNSCC management have been identified, but further analyses are required to properly validate and to precisely evaluate their clinical relevance. After an exploratory phase, the completion of large scale projects with stringent methodology is now necessary to transfer GEP from bench to bedside.
Authors: Marcelo Dos Santos; Ana Maria da Cunha Mercante; Fábio Daumas Nunes; Andréia Machado Leopoldino; Marcos Brasilino de Carvalho; Diana Gazito; Rossana Verónica Mendoza López; Paula Blandina Olga Chiappini; Paulo Bentes de Carvalho Neto; Erica Erina Fukuyama; Eloiza Helena Tajara; Iúri Drumond Louro; Adriana Madeira Álvares da Silva Journal: Mol Biol Rep Date: 2012-09-13 Impact factor: 2.316
Authors: Krzysztof Szyfter; Malgorzata Wierzbicka; Jennifer L Hunt; Alessandra Rinaldo; Juan P Rodrigo; Robert P Takes; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2014-10-30 Impact factor: 2.503
Authors: Antonia Kolokythas; Mitchell J Bosman; Kristen B Pytynia; Suchismita Panda; Herve Y Sroussi; Yang Dai; Joel L Schwartz; Guy R Adami Journal: J Oral Pathol Med Date: 2013-04-17 Impact factor: 4.253
Authors: Jennifer L Hunt; Leon Barnes; James S Lewis; Magdy E Mahfouz; Pieter J Slootweg; Lester D R Thompson; Antonio Cardesa; Kenneth O Devaney; Douglas R Gnepp; William H Westra; Juan P Rodrigo; Julia A Woolgar; Alessandra Rinaldo; Asterios Triantafyllou; Robert P Takes; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2013-03-07 Impact factor: 2.503
Authors: Andrew D Kelly; Katherine E Hill; Mick Correll; Lan Hu; Yaoyu E Wang; Renee Rubio; Shenghua Duan; John Quackenbush; Dimitrios Spentzos Journal: Genomics Date: 2013-04-03 Impact factor: 5.736
Authors: Anders Näsman; Mircea Romanitan; Cecilia Nordfors; Nathalie Grün; Hemming Johansson; Lalle Hammarstedt; Linda Marklund; Eva Munck-Wikland; Tina Dalianis; Torbjörn Ramqvist Journal: PLoS One Date: 2012-06-12 Impact factor: 3.240
Authors: Eric Van Dyck; Petr V Nazarov; Arnaud Muller; Nathalie Nicot; Manon Bosseler; Sandrine Pierson; Kris Van Moer; Valérie Palissot; Céline Mascaux; Ulrich Knolle; Vincent Ninane; Romain Nati; Roy M Bremnes; Laurent Vallar; Guy Berchem; Marc Schlesser Journal: Cancer Med Date: 2014-02-04 Impact factor: 4.452