Literature DB >> 20949280

Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells.

Junji Xing1, Shuai Wang, You Li, Hong Guo, Lei Zhao, Weiwei Pan, Fusen Lin, Huifang Zhu, Lei Wang, Meili Li, Lin Wang, Chunfu Zheng.   

Abstract

In this study, we presented the construction of a library of expression clones for the herpes simplex virus type 1 (HSV-1) proteome and subcellular localization map of HSV-1 proteins in living cells using yellow fluorescent protein (YFP) fusion proteins. As a result, 21 proteins showed cytoplasmic or subcytoplasmic localization, 16 proteins showed nuclear or subnuclear localization, and others were present both in the nucleus and cytoplasm. Interestingly, most capsid proteins showed enriched or exclusive localization in the nucleus, and most of the envelope proteins showed cytoplasmic localization, suggesting that subcellular localization of the proteins correlated with their functions during virus replication. These results present a subcellular localization map of HSV-1 proteins in living cells, which provide useful information to further characterize the functions of these proteins.

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Year:  2010        PMID： 20949280     DOI： 10.1007/s00430-010-0175-9

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  67 in total

1.  Identification and characterization of the UL56 gene product of herpes simplex virus type 2.

Authors:  Tetsuo Koshizuka; Fumi Goshima; Hiroki Takakuwa; Naoki Nozawa; Tohru Daikoku; Osamu Koiwai; Yukihiro Nishiyama
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

2.  Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1.

Authors:  Y E Chang; A P Poon; B Roizman
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

3.  Genetic analysis of the UL 15 gene locus for the putative terminase of herpes simplex virus type 1.

Authors:  D Yu; S K Weller
Journal:  Virology       Date:  1998-03-30       Impact factor: 3.616

4.  Deletion mutants of the herpes simplex virus type 1 UL8 protein: effect on DNA synthesis and ability to interact with and influence the intracellular localization of the UL5 and UL52 proteins.

Authors:  E C Barnard; G Brown; N D Stow
Journal:  Virology       Date:  1997-10-13       Impact factor: 3.616

5.  Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription.

Authors:  K L Carter; P L Ward; B Roizman
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

6.  Herpes simplex virus Us11 protein enhances recovery of protein synthesis and survival in heat shock treated HeLa cells.

Authors:  C Diaz-Latoud; J J Diaz; N Fabre-Jonca; K Kindbeiter; J J Madjar; A P Arrigo
Journal:  Cell Stress Chaperones       Date:  1997-06       Impact factor: 3.667

7.  The US5 open reading frame of herpes simplex virus type 1 does encode a glycoprotein (gJ).

Authors:  H Ghiasi; A B Nesburn; S Cai; S L Wechsler
Journal:  Intervirology       Date:  1998       Impact factor: 1.763

8.  Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins.

Authors:  F J Rixon; C Addison; A McGregor; S J Macnab; P Nicholson; V G Preston; J D Tatman
Journal:  J Gen Virol       Date:  1996-09       Impact factor: 3.891

9.  Purification and characterization of the herpes simplex virus type 2-encoded uracil-DNA glycosylase.

Authors:  T A Winters; M V Williams
Journal:  Virology       Date:  1993-08       Impact factor: 3.616

10.  Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27.

Authors:  W E Mears; V Lam; S A Rice
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103
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  20 in total

1.  A PY-nuclear localization signal is required for nuclear accumulation of HCMV UL79 protein.

Authors:  Lin Wang; Meili Li; Mingsheng Cai; Junji Xing; Shuai Wang; Chunfu Zheng
Journal:  Med Microbiol Immunol       Date:  2012-05-25       Impact factor: 3.402

2.  Probing of the nuclear import and export signals and subcellular transport mechanism of varicella-zoster virus tegument protein open reading frame 10.

Authors:  Mingsheng Cai; Shuai Wang; Jing Long; Chunfu Zheng
Journal:  Med Microbiol Immunol       Date:  2011-07-14       Impact factor: 3.402

3.  Nuclear localization signals of varicella zoster virus ORF4.

Authors:  Yizhong Huang; Jie Zhang; Mohammed Abo Halawa; Shanglong Yao
Journal:  Virus Genes       Date:  2014-01-08       Impact factor: 2.332

4.  Herpes simplex virus 1 serine/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production.

Authors:  Shuai Wang; Kezhen Wang; Rongtuan Lin; Chunfu Zheng
Journal:  J Virol       Date:  2013-09-18       Impact factor: 5.103

5.  Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-κB activation.

Authors:  Kezhen Wang; Liwen Ni; Shuai Wang; Chunfu Zheng
Journal:  J Virol       Date:  2014-05-07       Impact factor: 5.103

6.  Visualization of Marek's disease virus in vitro using enhanced green fluorescent protein fused with US10.

Authors:  Weifeng Mao; Taejoong Kim; Hans H Cheng
Journal:  Virus Genes       Date:  2013-05-24       Impact factor: 2.332

7.  Herpes simplex virus 1 ubiquitin-specific protease UL36 inhibits beta interferon production by deubiquitinating TRAF3.

Authors:  Shuai Wang; Kezhen Wang; Jie Li; Chunfu Zheng
Journal:  J Virol       Date:  2013-08-28       Impact factor: 5.103

8.  Herpes simplex virus 1 E3 ubiquitin ligase ICP0 protein inhibits tumor necrosis factor alpha-induced NF-κB activation by interacting with p65/RelA and p50/NF-κB1.

Authors:  Jie Zhang; Kezhen Wang; Shuai Wang; Chunfu Zheng
Journal:  J Virol       Date:  2013-09-25       Impact factor: 5.103

9.  Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-α-induced NF-κB activation by interacting with p65/RelA and p50/NF-κB1.

Authors:  Jie Zhang; Shuai Wang; Kezhen Wang; Chunfu Zheng
Journal:  Med Microbiol Immunol       Date:  2013-05-01       Impact factor: 3.402

10.  The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain.

Authors:  Christina Funk; Melanie Ott; Verena Raschbichler; Claus-Henning Nagel; Anne Binz; Beate Sodeik; Rudolf Bauerfeind; Susanne M Bailer
Journal:  PLoS Pathog       Date:  2015-06-17       Impact factor: 6.823
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