Literature DB >> 20948546

Protein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage.

Midori Shimada1, Mayumi Haruta, Hiroyuki Niida, Kazunobu Sawamoto, Makoto Nakanishi.   

Abstract

The DNA-damage-induced transcriptional suppression of cell cycle regulatory genes correlates with a reduction in histone H3-Thr 11 phosphorylation (H3-pThr 11) on their promoters that is partly mediated by the dissociation of Chk1 from chromatin. In this study, we identify protein phosphatase 1γ (PP1γ) as a phosphatase responsible for DNA-damage-induced H3-pThr 11 dephosphorylation. PP1γ is activated after DNA damage, which is mainly mediated by a reduction in Cdk-dependent phosphorylation of PP1γ at Thr 311. The depletion of PP1γ sensitizes HCT116 cells to DNA damage. Our results suggest that the ataxia telangiectasia, mutated and Rad3-related-Chk1 axis regulates H3-pThr 11 dephosphorylation on DNA damage, at least in part by the activation of PP1γ through Chk1-dependent inhibition of Cdks.

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Year:  2010        PMID： 20948546      PMCID： PMC2966955          DOI： 10.1038/embor.2010.152

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  27 in total

1.  A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.

Authors:  Michael-Christopher Keogh; Jung-Ae Kim; Michael Downey; Jeffrey Fillingham; Dipanjan Chowdhury; Jacob C Harrison; Megumi Onishi; Nira Datta; Sarah Galicia; Andrew Emili; Judy Lieberman; Xuetong Shen; Stephen Buratowski; James E Haber; Daniel Durocher; Jack F Greenblatt; Nevan J Krogan
Journal:  Nature       Date:  2005-11-20       Impact factor: 49.962

2.  Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe.

Authors:  Hiroyuki Niida; Shinji Tsuge; Yuko Katsuno; Akimitsu Konishi; Naoki Takeda; Makoto Nakanishi
Journal:  J Biol Chem       Date:  2005-09-13       Impact factor: 5.157

3.  Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

Authors:  Veronique A J Smits; Philip M Reaper; Stephen P Jackson
Journal:  Curr Biol       Date:  2005-12-15       Impact factor: 10.834

4.  Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse.

Authors:  Mark Swingle; Li Ni; Richard E Honkanen
Journal:  Methods Mol Biol       Date:  2007

5.  Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.

Authors:  Lyubomir T Vassilev; Christian Tovar; Shaoqing Chen; Dejan Knezevic; Xiaolan Zhao; Hongmao Sun; David C Heimbrook; Li Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-03       Impact factor: 11.205

6.  Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.

Authors:  A H Walsh; A Cheng; R E Honkanen
Journal:  FEBS Lett       Date:  1997-10-27       Impact factor: 4.124

7.  gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair.

Authors:  Dipanjan Chowdhury; Michael-Christopher Keogh; Haruhiko Ishii; Craig L Peterson; Stephen Buratowski; Judy Lieberman
Journal:  Mol Cell       Date:  2005-11-28       Impact factor: 17.970

Review 8.  Emerging roles of nuclear protein phosphatases.

Authors:  Greg B G Moorhead; Laura Trinkle-Mulcahy; Annegret Ulke-Lemée
Journal:  Nat Rev Mol Cell Biol       Date:  2007-03       Impact factor: 94.444

9.  Evidence that the endogenous histone H1 phosphatase in HeLa mitotic chromosomes is protein phosphatase 1, not protein phosphatase 2A.

Authors:  J R Paulson; J S Patzlaff; A J Vallis
Journal:  J Cell Sci       Date:  1996-06       Impact factor: 5.285

10.  Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability.

Authors:  Laura Trinkle-Mulcahy; Jens Andersen; Yun Wah Lam; Greg Moorhead; Matthias Mann; Angus I Lamond
Journal:  J Cell Biol       Date:  2006-02-21       Impact factor: 10.539
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  11 in total

Review 1.  What goes on must come off: phosphatases gate-crash the DNA damage response.

Authors:  Dong-Hyun Lee; Dipanjan Chowdhury
Journal:  Trends Biochem Sci       Date:  2011-09-18       Impact factor: 13.807

Review 2.  A peek into the complex realm of histone phosphorylation.

Authors:  Taraswi Banerjee; Debabrata Chakravarti
Journal:  Mol Cell Biol       Date:  2011-10-17       Impact factor: 4.272

3.  Human mitochondrial Fis1 links to cell cycle regulators at G2/M transition.

Authors:  Seungmin Lee; Yong-Yea Park; Song-Hee Kim; Oanh T Kim Nguyen; Young-Suk Yoo; Gordon K Chan; Xuejun Sun; Hyeseong Cho
Journal:  Cell Mol Life Sci       Date:  2013-08-02       Impact factor: 9.261

4.  Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin.

Authors:  Michael C Edler; Asma B Salek; Darryl S Watkins; Harjot Kaur; Cameron W Morris; Bryan K Yamamoto; Anthony J Baucum
Journal:  ACS Chem Neurosci       Date:  2018-06-01       Impact factor: 4.418

Review 5.  Chromatin and the DNA damage response: the cancer connection.

Authors:  Martijn S Luijsterburg; Haico van Attikum
Journal:  Mol Oncol       Date:  2011-07-03       Impact factor: 6.603

6.  Calcineurin regulates the stability and activity of estrogen receptor α.

Authors:  Takahiro Masaki; Makoto Habara; Yuki Sato; Takahiro Goshima; Keisuke Maeda; Shunsuke Hanaki; Midori Shimada
Journal:  Proc Natl Acad Sci U S A       Date:  2021-11-02       Impact factor: 11.205

7.  Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-κB signaling pathway.

Authors:  Takahiro Goshima; Midori Shimada; Jafar Sharif; Hiromi Matsuo; Toshinori Misaki; Yoshikazu Johmura; Kazuhiro Murata; Haruhiko Koseki; Makoto Nakanishi
Journal:  J Biol Chem       Date:  2014-02-28       Impact factor: 5.157

8.  HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy.

Authors:  Takayuki Seiki; Kazunori Nagasaka; Christian Kranjec; Kei Kawana; Daichi Maeda; Hiroe Nakamura; Ayumi Taguchi; Yoko Matsumoto; Takahide Arimoto; Osamu Wada-Hiraike; Katsutoshi Oda; Shunsuke Nakagawa; Tetsu Yano; Masashi Fukayama; Lawrence Banks; Yutaka Osuga; Tomoyuki Fujii
Journal:  BMC Cancer       Date:  2015-04-07       Impact factor: 4.430

9.  Response to DNA damage: why do we need to focus on protein phosphatases?

Authors:  Midori Shimada; Makoto Nakanishi
Journal:  Front Oncol       Date:  2013-01-31       Impact factor: 6.244

10.  A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation.

Authors:  Kazunori Nagasaka; Takayuki Seiki; Aki Yamashita; Paola Massimi; Vanitha Krishna Subbaiah; Miranda Thomas; Christian Kranjec; Kei Kawana; Shunsuke Nakagawa; Tetsu Yano; Yuji Taketani; Tomoyuki Fujii; Shiro Kozuma; Lawrence Banks
Journal:  PLoS One       Date:  2013-01-24       Impact factor: 3.240
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